ID   A0A3Q0QRD3_AMPCI        Unreviewed;       770 AA.
AC   A0A3Q0QRD3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000000085.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000000085.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q0QRD3; -.
DR   Ensembl; ENSACIT00000000087.1; ENSACIP00000000085.1; ENSACIG00000000069.1.
DR   GeneTree; ENSGT00940000154738; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07211; Pat_PNPLA8; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR045217; PNPLA8-like.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR24185; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   PANTHER; PTHR24185:SF1; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}.
FT   DOMAIN          436..631
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          178..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   770 AA;  86339 MW;  ED14AF8BA8855873 CRC64;
     MGRYLSVNLC SSSVNRILES YCKIRYTANL LRKGHCLAKA PLCFDLHRYS QLSPPQTFRL
     ATKAAFKKVK RSVTGSTSYR FLRDFTKEGR HPQTVRFYSS SNKDAFKAKA PVGIFEEAQN
     NFLLSSRGGC LGQSFNQLSR RTNTYFKRKE VVSLSGNASV VVSSPEYVCR SQRISKSQSA
     ATEQNIPESK DTTKTLKCED RQGNSVTSHS TQETSGLQLF HISSLVTRFG ENYNYVAHHI
     NSVFSQGLAK VKKQENLETG SATREANRRQ KRRKMQNAGI QSQVKLSSEQ ADIESQKTPE
     RLKSSSFTDY FCNPTSAIPG LLGAYRKLGP LSQTSNPKIA MSDPQLVLNR KQADEMTRVL
     MGSLRLASAP ETLTSRVEAF NEHLIHYPSC KEKTAVTLLR QRQNYKHDQE LQAALRETLA
     LIGYADPVKG HGIRVLSIDG GGTRGVVPLQ ILKLLEDETG KKIHQLFDYI CGVSTGAVLA
     FMLGLARFSI EECADMYRQF GSEVFRQNPL VGTVKMGWSH SYYNTETWES ILREKLGERV
     LIKTARDDFS PKVSAVSTVV NWGTSPKAFV FRNYNHKPGS VSRYAGGSGY QMWQAVRASS
     AAPGYFQEFT LQNDIHQDGG IILNNPCALA VHESRLLWPN QDFQCVLSLG TGRYDSAKKG
     PATSTSLRAK ISNVICSATD TEGVHTLLDD LLAPDVYFRF NPMLSTDVSL DENRPQALDQ
     LQRDTQNYLE RNRLKLARLC LVLSAEQVDT DMYDLPRTNP YDFCDLWLFL
//