ID A0A3Q0QW03_AMPCI Unreviewed; 426 AA.
AC A0A3Q0QW03;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Eukaryotic elongation factor 2 kinase {ECO:0000313|Ensembl:ENSACIP00000001431.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000001431.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000001431.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSACIT00000001489.1; ENSACIP00000001431.1; ENSACIG00000001111.1.
DR GeneTree; ENSGT00940000157839; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004686; F:elongation factor-2 kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd16967; Alpha_kinase_eEF2K; 1.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR047588; eEF2K_a_kinase_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR45992:SF2; EUKARYOTIC ELONGATION FACTOR 2 KINASE; 1.
DR PANTHER; PTHR45992; EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 64..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..320
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 8..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 48458 MW; 0735A95F555212D9 CRC64;
IMEDELMFSM EEDGSAKRPS AQRSALKHRA SSLSESNASE DDDEDHFICP ILDDSAREVS
NKTFIFLFFF FLFFPQATWL HAIEKAKSMP DPWAQFHLED IATEPCIRYR YNAVTGDWVQ
DQIHLKMAAQ VLPLTRKVHF RDSKKLSNFS HSSNWKSASN YVAKRYMETV DRSVYFEDXR
LQMEAKLWGE EYNRHRPPKQ VDIMQMCVVE MINRPGKALF HLEHYIEGKY IKYNSNSGFV
RDDNLRLTPQ AFSHFTFERS GHQLIVVDIQ GVGDLYTDPQ IHTAKGTDYG DGNLGVRGMA
LFFHSHLCNK ICKSMGLTPF DLSQAETSQL DCTNKLLKSA QTVLRGCEEH CGSPRVRTMS
ASRAPPLLSR LSETSSADES MSDVESIPCS PLILPYSPPA AAGSLGKLTI SRCKTNLLQY
HLFCKL
//
