ID A0A3Q0QWB5_AMPCI Unreviewed; 637 AA.
AC A0A3Q0QWB5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=SPARC-like 1 {ECO:0008006|Google:ProtNLM};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000002487.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000002487.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SPARC family.
CC {ECO:0000256|ARBA:ARBA00006404}.
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DR AlphaFoldDB; A0A3Q0QWB5; -.
DR STRING; 61819.ENSACIP00000002487; -.
DR Ensembl; ENSACIT00000002578.1; ENSACIP00000002487.1; ENSACIG00000002013.1.
DR GeneTree; ENSGT00510000046787; -.
DR OMA; GLHKTSH; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR015369; Follistatin/Osteonectin_EGF.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001999; Osteonectin_CS.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR PANTHER; PTHR13866; SPARC OSTEONECTIN; 1.
DR PANTHER; PTHR13866:SF25; SPARC-LIKE 1; 1.
DR Pfam; PF09289; FOLN; 1.
DR Pfam; PF00050; Kazal_1; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR SMART; SM00274; FOLN; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00612; OSTEONECTIN_1; 1.
DR PROSITE; PS00613; OSTEONECTIN_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..637
FT /note="SPARC-like 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018609477"
FT DOMAIN 427..484
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 595..630
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 66..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..81
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 637 AA; 72028 MW; F182A74C3B5B3B9A CRC64;
MRACLVFLCL LAATFALSVS SKVIVIIKLT SKIFSKYFSS LLLKDAITEE ANKPKILPTL
VTFEASSQEQ EDEELSSEDN ANKEDEEGAE KREKSTAVLL SEEELADLLK KEAEEDDEAE
ARELEEEEVG ADKGKVESSE AVEITEDQKK NLDSNSEAKT DLPDEEEVKE ETVEDVVEEK
VQKTTHSEKK KEPIGKMGDS EALPEEDGST ESVIPVDLDY AADSSLLQHL QTAPANVKTH
SDDTKSVSKT DIPDVKEKET NEKELASIAD DYEQGMQNTE AAHSEELELR ARLSGKEEEK
SKNDSGSHTK GKTRKQKKNQ RARKHSPHRD ETQPEQEQSQ QDPQESEGSN IDNTVQKAKR
RRAGKWGPLV GMNPVQIRAT VDLYPMARPS LGGGIHLPET PADLCENFRC KRGKMCKLDA
DNKPGCVCQE PSECPPSVNE FDHVCGTDNK TYDTSCELFA TKCNLEGTKK GHKLHLDYTG
PCKLIPQCVD TELVQFPLRM RDWLKNVLLQ LYEHDSMTPG FLTPKQRFRV KKIFESERRL
HAGDHSVELL AQDFEKNYNM YIYPVHWQFA QLDQHPSDRF LSHSELAPLR VPLVPMEHCT
SRFFEECDAD KDKQVSFKEW ISCFGIKNED MDVNLLF
//
