ID A0A3Q0QWP6_AMPCI Unreviewed; 1224 AA.
AC A0A3Q0QWP6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=N-acetylglucosamine-1-phosphate transferase subunits alpha and beta {ECO:0000313|Ensembl:ENSACIP00000002443.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000002443.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000002443.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the stealth family.
CC {ECO:0000256|ARBA:ARBA00007583}.
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DR STRING; 61819.ENSACIP00000002443; -.
DR Ensembl; ENSACIT00000002534.1; ENSACIP00000002443.1; ENSACIG00000001951.1.
DR GeneTree; ENSGT00390000006747; -.
DR OMA; MIDRVVM; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003976; F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; IEA:Ensembl.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0002063; P:chondrocyte development; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0016256; P:N-glycan processing to lysosome; IEA:Ensembl.
DR CDD; cd21600; RRM2_GNPTAB; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR InterPro; IPR010506; DMAP1-bd.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR041536; GNPTAB_reg.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR047141; Stealth.
DR InterPro; IPR031358; Stealth_CR1.
DR InterPro; IPR021520; Stealth_CR2.
DR InterPro; IPR031357; Stealth_CR3.
DR InterPro; IPR031356; Stealth_CR4.
DR PANTHER; PTHR24045; -; 1.
DR PANTHER; PTHR24045:SF0; N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA; 1.
DR Pfam; PF06464; DMAP_binding; 1.
DR Pfam; PF18440; GlcNAc-1_reg; 1.
DR Pfam; PF00066; Notch; 2.
DR Pfam; PF17101; Stealth_CR1; 1.
DR Pfam; PF11380; Stealth_CR2; 1.
DR Pfam; PF17102; Stealth_CR3; 1.
DR Pfam; PF17103; Stealth_CR4; 1.
DR SMART; SM01137; DMAP_binding; 1.
DR SMART; SM00004; NL; 2.
DR SUPFAM; SSF90193; Notch domain; 1.
DR PROSITE; PS51912; DMAP1_BIND; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50258; LNR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1180..1205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 437..467
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 700..796
FT /note="DMAP1-binding"
FT /evidence="ECO:0000259|PROSITE:PS51912"
FT DOMAIN 989..1024
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 643..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..118
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1224 AA; 139303 MW; D6DDFA0157303191 CRC64;
MVVVNSVLKL VQRQTYTCLS HRYGLYLCFG GIVLMIVSAF QFGEVLVEWS RDQYHVLFDS
YRDNVGGKSF QSRLCLPMPI DVVYTWVNGT DTALLRELKA VKEQLEEEQK ARRELLGKNA
SETTEVPKDS VKPECLLSHC IIAPMLALDP ALPANVTLKE LPSLSPSFAT AKELLLMNKP
FQPSTTISVI VFNSQAEDVS KEDQKFSVLR CYLTTDKEAP GLSRMQALAY LSGFPASYKE
TEQLRAKLPS VITSKIKQLY SEASIALLHL NTPQDFTDLT QQAKKNLTLD GKELTISPAY
LFWDLTAISQ SKQDEDVSAS RFEDNEELRY SLRSVEKHAP WVRHIFIVTN GQIPSWLNLD
NPRVSVITHQ DIFLNHSHLP TFSSPAIETH IHRIPGLSQK FIYLNDDVMF GKDVWPDDFY
SHSKGQKVYL TWPVPNCAEG CPGSWIKDGY CDKACNNSAC DWDGGDCLGA AGNSRFAGGV
GPGGAGGAGG QVWQFAGGLG GVAGTSYCNQ GCANSWLADK FCDQACNVLS CGFDVGDCGQ
EHFGELHHVT LLRNQSSYTL PVGEIRPYFS FEKFARRVSE AHISDSPVVR HTSVANKWKT
IHLLLLPGYN ATQIHYNLTF QRDDDTEFTM SFSVTVDTRE VSQTNVSRTS SKDAGKEPKV
TPTPEPVFPF SDIPEHKRGP KIKKWLPGEP QTIIEVPSLN VSLLPAALRK ELQKLEEKLQ
IGDITMKGYN LTKAELLKPY KTLAEKQQIP DSQLGKDDAD RVQKKPYKDL EGDDLKIKAE
SRNIQKNQNS KEEMSREDVA VRDKTVIPVN IDDKLAEDIM TETPYPLKAV IERPMTSKLL
NRPPPPKSAE SEAEPANAAP VGRRLQHFTS SDRGFLPWER RKYFQALLEE EERLDSEMAY
ETDGTATRRK LRDTFADSLR YVNKLLNSQF GFTSRKVPAH MPHMIDRLIM QELQDTFPQE
FDKTSGHRVR HPEDMQFAFS YFYFLMSAQQ QLNVSEVFDD IDTDHSGVLS DREIRTLATR
IHELPLSLQD LTGLEQMLIN CSKTLPTNLT QLHLVNPTQE AYYDPSMVTH HRTFIFYLFI
LMFEIMGEEE IAFKMVRTNV SHVVGQLDDI RKNPRKFICL NDNIDHSHKD AATVKAVLRD
FYESMFPLPS QFELPREYRN RFLHMEELQE WRVYRDKLKF WTHCVLVXLV IFTIISFFAE
QLIVLKRKLF PRRRVNRENN PERV
//
