ID A0A3Q0QX00_AMPCI Unreviewed; 2311 AA.
AC A0A3Q0QX00;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000002528.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000002528.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSACIT00000002620.1; ENSACIP00000002528.1; ENSACIG00000001768.1.
DR GeneTree; ENSGT00940000157157; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 23.
DR CDD; cd21702; JMTM_Notch1; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 30.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR12916; CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2; 1.
DR PANTHER; PTHR12916:SF4; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 16.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF12661; hEGF; 7.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 2.
DR PIRSF; PIRSF002279; Notch; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 30.
DR SMART; SM00179; EGF_CA; 28.
DR SMART; SM00004; NL; 2.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 20.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF90193; Notch domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 19.
DR PROSITE; PS00022; EGF_1; 28.
DR PROSITE; PS01186; EGF_2; 22.
DR PROSITE; PS50026; EGF_3; 30.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 57..97
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 99..136
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 137..173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 175..213
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 215..252
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 254..290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 292..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 332..368
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 369..407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 432..467
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 469..505
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 507..542
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 544..580
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 582..617
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 619..655
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 657..693
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 695..733
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 735..771
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 773..809
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 811..847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 849..885
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 887..923
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 953..988
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 990..1026
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1028..1064
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1066..1110
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1112..1150
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1152..1191
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1193..1229
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1232..1270
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1294..1334
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1335..1376
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1736..1768
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1803..1835
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1836..1868
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1869..1901
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1584..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1935..2016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2165..2192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2231..2311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1584..1599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1935..1971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1975..1996
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1997..2011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2231..2262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2270..2311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 87..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 126..135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 163..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 203..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 242..251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 280..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 320..329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 358..367
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 378..395
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 397..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 436..446
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 457..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 495..504
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 511..521
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 532..541
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 570..579
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 586..596
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 607..616
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 645..654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 683..692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 704..721
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 723..732
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 761..770
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 799..808
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 837..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 875..884
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 913..922
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 978..987
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1016..1025
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1054..1063
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1100..1109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1121..1138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1140..1149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1181..1190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1219..1228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1241..1258
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1260..1269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2311 AA; 251440 MW; 2901D52FA2CB2661 CRC64;
RYQHFKKNGQ FKIISKLTQV LKCDLTSFFN YYLKILQIPP LAVSRCRDGF LGNRCQFPDP
CTSSPCANSG ICRAMLRGNT VDFLCTCKPG FTDHRCQTDI SPCTSSLCRN GGTCDFDALE
GYICRCPPGW LGKQCERADP CTSNPCANSG QCSVFQSQYI CTCTPFFTGK TCAQDVNECD
ANPSPCKNGG ACVNEVGGYR CHCPPEYVGK HCESRYLPCN PSPCQNGGTC IQKGETSYEC
SCVPGFSGKN CNQNIDDCPN HECQNGGTCV DGVNTYNCQC KPEFTGQLCR EDVDECQLMP
NACQNGGTCH NTYGSYQCVC VNGWTGDDCS ENIDDCASAA CHQGSTCHDR VASFYCECPP
GRTGLLCQLG DACISNPCEK GSNCDTNPVT GNHFCTCPSG YVGTSCDQDI DECSLDGPNK
YTCYTGRHCE TDINECFSNP CHYGSCIDGL ASFSCQCNPG FTGRLCETNI NECLSQPCRY
GGTCQDRENG YVCICPKGTT GINCEINVDD CESNPCDYGA CIDKINGYEC ACEPGYTGAM
CNINIDECAI NPCHNGGTCI DGINSFTCLC PDGYHDTTCF SQVNECLSNP CIHGHCEDKI
NGYKCLCDSG WSGKNCDINN NECESNPCMN GGTCKDMTSG YVCTCRMGFT GPNCQTNINE
CASNPCLNQG TCIDDVAGYK CNCILPYTGE NCETLMAPCS SKPCKHGGLC QESEDYLNFS
CVCPEGWQGQ TCEVDIKECV KNPCHNGATC QNTLGSYRCS CKPGFTGRNC ETNIDDCKPN
PCSNGGSCND EVNGFVCTCP AGFRGTACEE DINECESNPC KNGANCTDCV NSYTCTCPPG
FSGIHCENNT PDCTESSCFN GGTCVDGINA FTCLCPPGFT GSYCQHDINE CDSKPCLNGG
TCQDSYGTYK CTCPHGYTGL NCQVGRGGSR RGETRRFKIL CVPRRAPSFA VRLGVDVAHL
CHNSGQCLDA GNVHYCHCQV GYTGSYCEEQ VDECNPNPCQ NGATCTDFLG GYTCKCMPGY
LGTNCSVEIN ECFSQPCQNG GTCIDLINTY KCSCPRGTQG VHCEVNIDDC NPFTDPVTKE
PKCFNKGKCV DGVGGYHCTC PPGYVGERCE GDVNECLSNP CDPRGTHSCI QLTNNYRCEC
RTGYTGQHCD MVFDGCKGKP CRNGGTCAVA SNTPHGFICK CPPGFTGSTC EYDSQACGIL
HCHNGGTCIS GYKSPTCLCT PSFTGPECQY PTNSLCNSNP CYNGGTCEYT SEAPYYHCVC
PTKFNGLRCH ILDYNFRGGF GVDILPPTEV DVPCGIPECE ESKYNKHCDA ICNNHECGWD
NGDCSLNFND PWKNCSAALQ CWRYFNNGQC DSQCDNCKRF KCEWDGLDCA SNMPEKLAVG
QLVLVVHITP EHLLNNSFGF LRELSRVLRT NVVFKKDTKG EMMVYPYYGD EHELKKYNVK
RSVDSWSEVP GKVLNVVKRS LYDVAGRSKR VKRELDHLQI RGSIVHLEVD NRQCVQQSTE
CFQSTSDAAA FLGALESSGK LDVPFTIEAV FSGVEPEPSQ PLYPIYLVLG GLGMLAFLGV
GMVAARKRRH EHGRLWLPEG FKTTETSKKK RREPVGEDSV GLKPMKNASD ISLMDDTHNE
WGEDEPSDAK RFRFDEQPAL EADDQTDNRQ WTQQHLDAAD LRIPSIAPTP PQGEIENDCL
DVNVRGPDGF TPLMIASCSG GGLETGNSEE EEDASANVIN DFIYQGANLH NQTDRTGETA
LHLAARYARS DAAKRLLEAS ADANIQDNMG RTPLHAAVAA DAQGVFQILI RNRATDLDAR
MHDGTTPLIL AARLAVEGMV EELINCHADV NAIDDFGKSA LHWAAAVNNV EATIVLLKNG
ANKDMQNNKE ETPLFLAARE GSYETAKVLL DHFANREITD HMDRLPRDIA QERMHHDIVR
LMDEYNLVRS PPMHGGSLST TLSPPLCSPN GFLGSMKQPQ PQGQGQSKKA RKPSTKGIGC
KEGKDMKVKK KNSQDGKSGN LLDSSAVLSP VDSLESPRGY VSDVASPPMM TSPFQQSPSV
SLNHLQGMSD AHLAVNHMVM PNKQELARMQ FDPMPPRLTH LPVPVSSGQS AMNGQCDWLS
RIHGNMSQPG QYNPMRGTPG GQGGLHQGGQ HGMMATTLHN GHPNSSLSQM MTYQGIQNTR
LGPQSHIMQQ QQQQQSIQLQ HQNSNTTNTQ NFISGELSSP ELQQGTGNST MPIHTILPQE
TQIMSSSINQ SMPSTQFLTP PSQHSYSGPI DNTPNHQVQV PDHPFLTPSP GSPDQWSSSS
PHSNMSDWSE GISSPPTSMQ SQIGHIPEQF K
//