ID A0A3Q0QYG0_AMPCI Unreviewed; 4242 AA.
AC A0A3Q0QYG0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Spectrin repeat containing, nuclear envelope 1b {ECO:0000313|Ensembl:ENSACIP00000002481.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000002481.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000002481.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR STRING; 61819.ENSACIP00000002481; -.
DR Ensembl; ENSACIT00000002572.1; ENSACIP00000002481.1; ENSACIG00000001765.1.
DR GeneTree; ENSGT00940000154481; -.
DR OMA; THTEMGR; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 19.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR PANTHER; PTHR21524:SF7; SPECTRIN REPEAT CONTAINING, NUCLEAR ENVELOPE 1; 1.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 8.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 26.
DR SUPFAM; SSF46966; Spectrin repeat; 23.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..4192
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TRANSMEM 4190..4211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 4214..4242
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 4184..4242
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 1456..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1766..1785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 359..410
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1228..1286
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1334..1402
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1801..1828
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1975..2002
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2037..2064
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2513..2540
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3256..3309
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3925..3980
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1458..1486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4242 AA; 487506 MW; 1BFA0E09BE948E43 CRC64;
MADADRVLAR LGLSERQHLQ QLISDTQSEV ESLSVKVMQR RKHLSKAFTE RTHFLMAVSQ
SISWVQQNEK KAQAEEYIAL LPDDLAKQVR TCRNIQSSLK AYQSELTSLW SQGRDLMRDA
SEEERNEILT KLQELQSIFD KTLHRCGQKL QELEKVLISR KYFKTDLEKI CQWLKQADIV
TFPEINLMVG DAELEAQLLK YQQIVEQAIE YENLLLIVQR AGQEILPTLN EVDHCYLDEK
LNTLPQQYNS ILALAKEKQE KIQQAIITRN EYKSFIDITH KALKELEEQF NNLGTQPVGL
QTEEVVSLQS DYKAIQKDLS NLGLAVSELN QKKEGFRSTG QPWRPEEMTQ LVSLYNGLKR
LVEQKVEHLD ETLESFEDHK AMAMQVDSEL KATKEQLVKV NAETQSAEER LKNYHALAGS
LQSANSHLSR LMEQMDTLAP RVDQAAHDAS KEQVVLWQEE LRSLQAAVGE LIEECENRFI
QSKDFETEMK RTLDWLQQVR DDLDCAVIVD VRVEKVQEEI RKQQIMQEEV QSRLRIVAAL
SSREKHEYIS ANELVPAHVD TSLEEMAKMQ ADVQKALTAK QVGISLEALV LCQKYHFRMQ
AACEWLEDAV SFLQQASLGV DVENYEECLR QQANILATEQ EFLIHLEELQ TLLPQLENLV
NPIAKEQLRV SVDSAKQRGV EVRDQLQCHQ DVLHSCVAQW KSYQEARQTV IELMNEAEKK
LTEFSTAKAA TGQEAEDNLS IFQSLVSLVN GFQEKLSGLE EQAAQLELVG SDASKATISR
SMTTVWQRWT RLRSVARGQE RVLEDTAQEW RTFREKMVKV KTVCDELQSR FPDSAVEKAS
KATLQSLLDQ HDLLSQDLER ELSSLTLLRQ YALSLLHDVE VPSPTNGQDE LPSLKEIRAV
QDRMESLLTQ SRTKRAQAAQ ELRDREEVEK ELSVVKAWIQ ETRELLLNPT PDIDSLLQEL
EVVHGDVITY RQNVDKLAEQ QQSKYLDLYT ILPSEISMQL AEVSLALGAI EDQVLSKERE
NQKTREIKED FSSRVHDMSE KLKAISNKFK EKSPDVDHAK EEVKSLFEDL DSCGRTLAEL
DAAVQEFGRR NPLLAKQLSD AISKLSEMHH HTSRLADCRN NWLKKAVCYL DEYNEMLDFI
VRWSEKAKSL VRANIIWNSS VHLQEQIRMY QAVLRESREL HGDLESMAEK VELLSEVLQV
ESMSQQVCEL SRHTEELQQS IKTRLQSLQD ANKSMEALEY EVKALHVALE QVQATLTSPE
LARQSLKEQL AQRQRLLADM ESFKQQVQAV QLCQSALQVP EEVMPNLAIC RTALRLQQEA
SQLQHVAIQQ CNILQEAVVQ YEQYEQEVRD LQGLIEEAHR VIQDRPIPTN NIQELQAQIL
HHEELAQKIK GYQEQIASLN SKCKMLAVKA KHATMLLTVT DVEGLPEDLQ EMDGEKSKKS
AAQMTAGRCH TLLSPVTEES GEEGTNSEIS SPPVCRSPSP ITHTEMGRGT LTRAPIQELY
DPTFESVANL DDLQRSWESL KNVISEKQRS LYEALEKQQH YQGSLQSISS KMEALEAKLC
EPLEADKSPD SHIKAHEGLI EDIQSVQEEI DRLQTSFTED LATDAVDSDM ADHLAMQSSL
AVLAERMATI HMKASGKQQV LEERVSDRLE GQLQEQVVQL YHTQADELDR WLAKMRSAVT
SLFHLKPEEE TDMENQLAEC QNMLLEIEEK VLALSELSVH SENLLRGGRT DTREEAEHLA
RKLRTLKGGL LELQRMLQDK QVNIQGSLQE QEDSESESSL SQSPSVQDWL ALARTTRTQQ
HQDSLQRQRE LEEQLAEQKK LLQSVASRGE EILIQQASPS TALAERETQV GREQMRQRWE
SLRLELKTKL QLLQKTLEQD HKQPVQILLF LINIQVAEME QQLYTAVSNT SSWLDSVENN
VFSGSVLLAE NAETQLQKQE VQLALFTELQ LLQTALIETK CQILQALAGA MDRPASKQLE
VIASAEESLK DFEQRITELK TRGAALHADQ ISVNKLLKLQ DSYEELVMTV GSRRSGLNQN
MALKEQYERA LQDLKDLVDT AKDKMAADQR IIASSVEEVQ NHLDKHKEFF QGLESHMILT
ETYFRKISGL MLPKENQALE QTLAEAQSVL KEAHSKGVEL ECILETWCRL VQDYQSLNRH
LEAVEGSIPS AGLVEETEER LMDRISLYQG LKGRLTEHQH KLYQVLDEGK HLLLSVCCPA
LENQLTLLGE HWLNNTAKVN KELQRLEAIL KHWTRYQREC AEMSEWLQSA LERLEFWNTQ
AVLVPQELET VRDHLSAFLE FSKEVEGKST LKSSVVNEGN QLLRLKKVDT VVLRSDLARI
DTQWAELLTR IPVVQEKLHQ IQMEKLASRH AISELFNWIA LMENVIEEDE ENLKSAVGSS
VIQDYLQKYK GFRVDLSCKQ LTVDFVNQSV LQLSGQDVES KRSDKTDFAE RLGAMNRRWQ
ILQGRINERI QFLESLLEMW LEYESSVQAL KSWMATQEER LKRKHRIEDL TSVQNALKDC
EEMEELVKEK EKELERVEEQ GCALVQNKTD EACAIVMETL QGVNHTWANL DHLIGQLKIS
LKSVLDQWTL YKHASEEING YLMEGRYSVS RFRLLTGSLE AVHLQDLQGE LEKQESSLRK
FGAVTHQLLR ECHPSVSDSL NNALKDVNAR WTGLLEEIGE RLRSSKALLQ LWQRYKELYE
QSCNSIQLQE EKANQLLKTT CSKDIADDEV SDWIQECSVS EASLQVLQEL GEQLKQQVDT
SAASAIQSDH LSLTQRLAAV EQALTRQLTT LQTGVQDYEI FNHQLESLGS WVVEAEEALK
VQDPNGSTDL TVIQDRMDEL KRLMLKFSSM APELERLNEL GYRLPLNDSE IKRMQNLNRS
WSTASAQATE RFSKLQSFLL QQQTFLEKCE TWMEFLVQTE ENLAVEISGN YQSLIEQQKA
HELFQAEMFS RQQILHSIIS DGQRMLEQGQ VDDRDEFNLK LALLSNQWQG VVRRAQQRRG
IIDGLIRQWQ RYREMVDKLR KWLLEVFHRT EALQAGNTVP LQQARAMLDG VQMKEKVLQR
HQGSYILTVE AGRQLLLSAD SRAEAALQAE LTDIQERWKQ TSIRLEEQKK ELYTLLKDWE
RCEKGICGSL EKLRAFKKQL SQPIPNHNED LQAEQIRCKD LENTFDGWTG DLAHLTVLRE
SLSCYISAED LSVLQERIEL LHRQWDEICH QLSLRRQQVS EKLNEWTVFT EKYKELCEWL
TNMESKVSQN GDISIEEMIE KLRKDYQEEI TVAEENKLQL HQLGERLARA SHQSKATEIE
QKLNKVSDRW QHLLDLIGAR VKKLRETLVA VQQLDKNMNS LRSWLAHIET ELSKPIAYDT
CDFQEIQRKL DLQQELQRDI EKHSTGVASV LNLCEVLLHD CDACATDAEC DSIQQATRSL
DRRWRSICAL SMERRLKIEE TWRLWQKFLD DFARFEEWLA TSEKTAALPN SSGVLYTVAK
EELKKFETFQ RQVHESLTQL ELINKQYRRL ARENRTDSSC QLREMAHDAN QRWDNLQKRV
ASILRRLKHF ISQREEFETA RDGILVWLTE MDLQLTNIEH FSECDIQAKI KQLRSFQQEI
SLTTAKIEHI FHQGEALIEK SEPLDAAVIE EELEELQRYC QEVFGRVERY YKKLIRLPLA
DDDTEVSFSD RELELDEHCD LSSLPWSERL GDGFLSPLPS SGRSASLAAQ FRNERSGRDT
PASVDSIPLE WDHDYDLSRG LESAISVKPT AECMYCIMFL PDVVIPESPE AYVKLTEQTL
RSSTAADSHI HPLDVSRLHL QQTDSSRSRT STSTEMDGSY MGYLRLMGEC RGSIDTVKRI
GSELKEEEDT VSGLADPSSS ESQTSGVIER WELLQAQDLS KEMRTKQNEQ QWQQLNSDLN
KIWIWLGETE EELEQQRKLD LGTDIQTIEL RIKKLKELQK AYDKRKAIVL SINLCSVEFL
QSETDESREL QGKLKDMNNH WDKLGSALEE WRSSLQEALM QCQEFHEMSH GLLLWLENID
RRRNEVVPID PIQDSDTLHE HHKTLTQIRQ ELLDSQLKVA SLQDMSLQLL VNSQGSDCLE
AKEKVHVIGN RLKLLLKEVT RDLRELAKIL DITSSQQDLS SWSSADELDT SGSLSPVSGR
STPSHRRSCV LRCECLCVCV SRPHSDAGSA SFPSDSETRS ARRSSFLRRV FWVALPLQLF
LLLLVVFAFL LPMSEEYYCA QSNNFANSFY PMLSYTNGPP PV
//
