ID A0A3Q0R1X1_AMPCI Unreviewed; 736 AA.
AC A0A3Q0R1X1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Forkhead box O6 b {ECO:0000313|Ensembl:ENSACIP00000004033.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000004033.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000004033.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A3Q0R1X1; -.
DR STRING; 61819.ENSACIP00000004033; -.
DR Ensembl; ENSACIT00000004166.1; ENSACIP00000004033.1; ENSACIG00000003193.1.
DR GeneTree; ENSGT00940000165224; -.
DR OMA; PHPAHDY; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032067; FOXO-TAD.
DR InterPro; IPR032068; FOXO_KIX-bd.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR PANTHER; PTHR45767:SF5; FORKHEAD BOX PROTEIN O6; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16676; FOXO-TAD; 1.
DR Pfam; PF16675; FOXO_KIX_bdg; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
FT DOMAIN 116..210
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 116..210
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 192..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..609
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 80004 MW; C8C41A53D33ABB8E CRC64;
MLMMMENSGM DVHQVDIDSE FEPHGRSRSC TWPLPCPEDF PGGEEANRGL ALASVKVEQY
NVPACRGERK GGAPAEIKHP AGAPAPVVAA PACMSGAALD VAGQLRKAKS SRRNAWGNLS
YADLITRAIE SAPEKRLTLS QIYDWMVRFV PYFKDKGDSN SSAGWKNSIR HNLSLHSRFI
RVQNEGTGKS SWWMLNPEGG KMGKGPRRRA SIDNGTRYLK TKGRISRKRA GAMGLGRGQG
QGAGPAMQGS PEHGSPAAKG GVGIGGEEYD SWTDLHSRTS SSGSTLSGCL SPILAEAEAD
EPEEGGLSSS ASPRIYPSPT STRSPALGTG GHCPTVELPQ LTDLTGAISL DESGYPQPPQ
IKCNGYPYVP GPKAEGSYCG LMYGQPSMGM LRHHTPMETI QENKPVSFQR PVRGYSENNA
LQSLLTGGPS YCNKDTVLSQ GRETHTLMTQ GTNGVHSQHS HNQNRSHSHN QNHNQEHTRN
PSLHNDHDQN TTHHQNHNQG HKHQASLDYA HSHKPHPSHD YGSSHEHNHS NKVNPSHDHN
PHSTQSHMHN HNPHNSHNPM HSGPHHQALS PRVSTDILQP YSLKTSNHYG PRPHLPTSPS
LPPNPAGIMD VPQDPCRLAS APHPRHQPYP GAHHQGMTDS WHGFYHNNHQ SGNAGYQGQQ
HNSQSRMASD LEMENVPNSL DCDVDSILLN DFMDTENMDF NFDGSLSQGV GMGMGMSLGA
FACPAPSHSN QSWVPG
//
