ID A0A3Q0R4S2_AMPCI Unreviewed; 2878 AA.
AC A0A3Q0R4S2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=CHD9 {ECO:0000313|Ensembl:ENSACIP00000005316.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000005316.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000005316.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR STRING; 61819.ENSACIP00000005316; -.
DR Ensembl; ENSACIT00000005481.1; ENSACIP00000005316.1; ENSACIG00000004097.1.
DR GeneTree; ENSGT00940000155706; -.
DR OMA; PGTACQF; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18663; CD2_tandem_CHD5-9_like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.40.5.120; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR PANTHER; PTHR46850:SF1; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR Pfam; PF07533; BRK; 2.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 2.
DR SMART; SM00592; BRK; 2.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 2.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 798..867
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 897..1073
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1182..1338
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 86..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1461..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2007..2231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2381..2401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2689..2735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2767..2878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2007..2035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2136..2231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2717..2735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2773..2788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2814..2843
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2846..2870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2878 AA; 320179 MW; 09823CF7BD2D9FCF CRC64;
MFFFLHFRAG TLYSQHAVAL QTGTWGPAWI HWCSRGSSDP LTSAMDFFND PSLFGGGLEG
LDEDGFPSAP SLVDELNLTA DFEPLEVEPL GPGKHQDMMP PVSTQQPMPS YSQSMGHYIG
IKASVGQSFS GSQGINEGMI TEPHGSYHSA PMNQVPQSNG LFCNSGSPMW GNQDQNGNMY
QPLPQQQLCH QQQQLQSQQL HGGQSSSQQQ IHHTQQQVQH QLTVREQQFH SRGVPSKPFL
EMSVTCLQTQ PQQGNYQLVR GCQAFPGAGL EDSNLPFPMH SSSIVHSLPT CSVSSASAYQ
PTQYPAYPGE PELPSLNEQS LSSAPVSRPT NTTAPLTSTV PELAGTPCQF SSMVRLSQQH
TRTPVSQAEE CSFRAVRCXG ETQGNCKSSE IFGESMRCYP NMTSHLPSEQ PQSCRVINTN
GYQTLGDSLL PSAAHDGDFD GLEPPDLLPD LLPQLEHAFK QEDKSNCSWA DTTQEVGIEY
RKPSPIEYNE DKVTHFTIFS SSSLCLEPLS SSSSSSSSSS SSSSSSSSSE KRVPRRTHHP
MESTPQDKQE KANRIISEAI AKARQRGEKN IPRVMSPESF PSSSSQYKAH RDHEHKGNGK
ARLKEKACRK ACIVPSSKPK QKAKIGKIVI KIGKKKRRKQ ESSEESDDDP PPRHTLKDDS
KRRSNRQVKR KKYAEELETR LSDEEVKVIV KAKKTSTAPP KEPALQLFVE NPSEEDAAVV
DKIMSSRIVK KEVNIQYCYF VCVCVCVSSY LHCEWATEQQ LEKDKRIQQK IKRFKMKQAQ
RALFFADMEE EPFNPDYVEV DRVLEVSYCE DKDTGEEVVY YLVKWCSLPY EDSTWELKDD
VDQSKIEEFE XLQAAKPDSR RVERPPANLW KKKEQSRQYR NGNSLRDYQL EGVNWLLFNW
YNRRNCILAD EMGLGKTIQS ITFLEEIYRV GIKGPFLIIA PLSTIANWER EFHTWTHLNV
IVYHGSMVSR QMLQQYEMYF RDAQGRVIRG AYRFQAVITT FEMILGGCPE LNAIEWRCVI
IDEAHRLKNK NCKLLEGFKL MNLNNYACIL FKHTIFSPHT SAVQKLQGIL KPMMLRRLKE
DVEKKLAPKE ETIIEVELTN IQKKYYRAIL EKNFSFLAKG AGQANMPNLV NTMMELRKCC
NHPYLIKGAE EKILEDFREV HSPTAPDFHL QAMVQSAGKL VLIDKLLPKM KAGGHKVLIF
SQMVRCLDIL EDYLIQRRYL YERIDGRVRG NLRQAAIDRF SKPDSDRFVF LLCTRAGGLG
INLTAADTCI IFDSDWNPQN DLQAQARCHR IGQNKAVKVY RLITRNSYER EMFDRASLKL
GLDKAVLQSM SGRDNSLGGG TGGGQQLSKK EIEDLLRRGA YGAIMDEEDE GAKFCEEDID
QILQRRTKTI TIESEGRGST FAKASFVASG NRTDISLDDP NFWDKWAKKA DIDVDMVNGR
NSLVIDTPRV RKQTRPFSAT KDELAELSEG ESDNDESKPK LRRNYDRLNS YGRTECFRVE
KNLLVYGWGR WKDILNHGRF KKQLTEWDVE SICRALLAYC LVHYRGDDKI KSFMWDLIAP
TEDGRTKELQ NHLGLSAPVP RGRKGKKMKT QSSAFDIHKA EWLRKHNPEH MLQDDGYKKH
LKHHCNKVLL RVRMLYYLKQ EVIGSQAQKV LDGVDSSEIK IWVPEPDNSE FPALWWDAIC
DKCLLLGVFK HGYEKYNTIR ADPTLCFLDR VGKPDEKAIA AEQRGNDFMD GDVDDPEYKP
APALIKDDME DDASSPGDLV ITDSAGGDAY WPSPSVLTAR LRRLITASQR YTKSRQILHI
HQAQSQSSQQ TMVLAAPLCP LPPTLNDTLN PKMAAKIERQ QRWTRREEAD FYRVVSTFGV
VFDPNLGRFD WTKFRAMARL HKKTDESLQK YLCAFTAMCR RVCRLPPKEG VDPSLNIQPI
TEERASRTLY RIELLRQVRE QVLRHPLLYE RLPLCQMSSD LPVWWEAGTH DRDLLIGAAK
HGVSRTDYHI LRDPELSFMA AQRNYSQTKA AQQQSRTSTP LLHPQYQTAT SALTGSPLPP
LPPPTQRDAD PCGVVPKVEP ASEGEEGKEK PGASWTPTQA PATPTGLEEK PVSVTRDNER
QMVAARTKPL TPNSSERKPK KTKRGRREAR HGSESDSDGS SSSTSSRSSS SSSSSSSSSS
HSGSSSSSSS SSCSSGSSSS SSSSSSSSDD SETTTVKGFD EDSVASLSTT QDETQDTHVA
ENGISNSSSH PFQGGGYMLA ASYWPKDRVI INRLDSICQA VLKGKWPGTR RVYEPGGAVA
SFYTTKLLDN ANSMCEDPSA SPQGSKVTKH VAENKEFSVK LNDEGGLKLT FQKQGLPLKR
PLESEEGPQA QQQYLARLHE LQSASDTGLA DITKPQCSFQ TGAPNGVIDG QPVVKRRRGR
RKNVEGMDLL FMNRSRVPAV PDKVSSGFNS GQVPADTESR VPVINLKDGT RLAGDDAPRR
KDLDQWLKEN PGFVADTGAF ICMQFHFQDG RPKQKRHRCR NPNKIDVNSL TGEERVQIIN
RRNARKIGGA FAPPLKDLCR FLQENPEYGV PPEWADVVKQ SGYLPESMFD RILTGPIVPE
EVSRRGRRPK NPLAKAAAAA AAAAAAPSNA AASALGLNPL LANGLLSGMD LTSLQAFQQN
LQSLQSLQLT AGLMGLPSDA SNLAASNLAA MFPMMLSGVA GLPNLLSMGS LLGKPAQEGE
PSASKAPSHT SDTKGERTEG SNTTPSSTSS SASSATATQS ASAASAASSQ PLSLNPLLLS
SMLYPGMLLT PGLNLPVSTT QPQSSNSNPT LPTAPPLPSA SQSLRQETQQ PRGDKDEEEE
DDEVLGEALD EGEEEEEEES TEQKDNSGPE GSGKAESSSS ESGNSSSSSD DSDSSDED
//
