ID   A0A3Q0R510_AMPCI        Unreviewed;       755 AA.
AC   A0A3Q0R510;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Amyloid beta (A4) precursor protein-binding, family A, member 2b {ECO:0000313|Ensembl:ENSACIP00000007179.1};
GN   Name=APBA2 {ECO:0000313|Ensembl:ENSACIP00000007179.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000007179.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000007179.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q0R510; -.
DR   STRING; 61819.ENSACIP00000007179; -.
DR   Ensembl; ENSACIT00000007393.1; ENSACIP00000007179.1; ENSACIG00000005608.1.
DR   GeneTree; ENSGT00940000158943; -.
DR   OMA; MSPEHSG; -.
DR   Proteomes; UP000261340; Unplaced.
DR   CDD; cd00992; PDZ_signaling; 2.
DR   CDD; cd01208; PTB_X11; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR12345:SF12; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2; 1.
DR   PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR   Pfam; PF00595; PDZ; 2.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50106; PDZ; 2.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          386..561
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          574..659
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          665..741
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..140
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..205
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..279
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..340
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  83456 MW;  A2749C5F2348705F CRC64;
     MAAPGSASCP TPHPTESRDL KALPARQRPH RYPKEPKPLP HSCKAQYSSP KSQDVGRSHP
     EADAHAEVEV KRYSNHEPDA ELQDQRPATP STPEHSHDQD DPNQADFHDG GDSLDDDSSS
     DYINNTSDDD DYDDGLAEED EGVTYYIRYC PEDDSYLEGM DCSNQGDCGS HTDESQEAVE
     GWAEEGEGES EDYCPNEEED EEGDEEERHG RAYIGDYYAP EDNGNSVRVS PYRSRKVLVV
     EGETGEEAEE DIDQIVAEIK MSMSMGSLSS GTDQSPEELA QDPAPSDYAH SKPDATPYPP
     PHHRHDSRPK SLNLPSMHHN NPDLQRGHKV HPHSPDDRQR WPQEQVSNGA EQPRKQQRSD
     LNVPLENNNV PEVRFPGPCE PEDLIDGIIF AANYLGSTQL LSERNPSKNI RMMQAQEAVS
     RVKSADGDAQ TLTEVDLFIS TQRIKVLNAD SQETMMDNAL RTISYIADIG NIVVLMARRR
     MPRTASQDCI ETTPGAPEAK KQYKMICHVF ESEDAQLIAQ SIGQAFSVAY QEFLRANGIN
     PEDLSQKEYS DIINTQEMYN DDLIHFSNSE NCKELQLEKS KGEILGVVIV ESGWGSILPT
     VILANMMNGG PAARSGKLSI GDQIMSINNT SLVGLPLATC QGIIKGLKNQ VQVKMNIVSC
     PPVTTVLIKR PDLKYQLGFS VQNGIICSLM RGGIAERGGV RVGHRIIEIN GQSVVATAHE
     KIVQALSNSV GEIHMKTMPA AMFRLLTGQE TPMYI
//