ID   A0A3Q0R555_AMPCI        Unreviewed;       752 AA.
AC   A0A3Q0R555;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=N-acetylglucosaminidase, alpha {ECO:0000313|Ensembl:ENSACIP00000004345.1};
GN   Name=NAGLU {ECO:0000313|Ensembl:ENSACIP00000004345.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000004345.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000004345.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q0R555; -.
DR   STRING; 61819.ENSACIP00000004345; -.
DR   Ensembl; ENSACIT00000004486.1; ENSACIP00000004345.1; ENSACIG00000003424.1.
DR   GeneTree; ENSGT00390000005900; -.
DR   OMA; YGQPFVW; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 1.20.120.670; N-acetyl-b-d-glucoasminidase; 1.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR007781; NAGLU.
DR   InterPro; IPR024732; NAGLU_C.
DR   InterPro; IPR024240; NAGLU_N.
DR   InterPro; IPR024733; NAGLU_tim-barrel.
DR   PANTHER; PTHR12872; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR12872:SF1; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   Pfam; PF05089; NAGLU; 1.
DR   Pfam; PF12972; NAGLU_C; 1.
DR   Pfam; PF12971; NAGLU_N; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..752
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018522784"
FT   DOMAIN          43..125
FT                   /note="Alpha-N-acetylglucosaminidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12971"
FT   DOMAIN          140..475
FT                   /note="Alpha-N-acetylglucosaminidase tim-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF05089"
FT   DOMAIN          483..741
FT                   /note="Alpha-N-acetylglucosaminidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12972"
SQ   SEQUENCE   752 AA;  85935 MW;  BEDAC816200FB680 CRC64;
     MSPRSGCCLA LSVVFCLFVS ACCRFPALDH IKPRTSDKAQ GRAVTELLKR LLGNRSTEFI
     VSVNRSLSND SLDMCELRST KNNKIVATGS TGVAVASGIY NYLKYFCNCH VSWSGNQLDV
     PRPLPKLTGV LRINTPHRFR YYQNVCTFSY SSVWWDWPRW EREIDWMALN GINLPLAFTG
     QEALWQEVYR ALGLNQSEIE EFFSGPAFLA WNRMANLFKF GGPLPQSWHV NQLYLQFKIL
     ERMRSFGMIP VLPAFSGNIP KGILRLYPEA RITRLGPWSH FNCSYSCSYI LDPQDPLFHQ
     IGSLYLSQVV KQFGTDHVYN TDTFNEMTPP SSDPTYLSAV SRSVFASMTA VDPQAIWLMQ
     GWLFFSDAAF WKPAQIQALL HGVPLGRMIV LDLFAETEPI FSYTESFYGQ PFIWCMLQNF
     GGNSGLFGTV GSINSGPFKA LHFPNSTLVG IGMTPEGIQQ NPVMYELMSE LAWRKEPVNL
     AKWASLYAVR RYGNTQENLT TAWRLLFASI YNCTVPHYRN HNHSPLVRRP SFRMNTGLWY
     DPADLYKAWK LIMDAAPSLM SKETFRYDLV DVTREVLQVL TTSFYQDIAD AFKNQKLSEL
     LTAGGVLVYD LLPELNRLLS SDQNFLLGTW LEQARSLALD DKEAQLYDMN ARNQITLWGP
     SGEILDYASK EWGGLVEDYY AQRWGLFVQT LVECLNSGQP FKQDTFNQAV FQIEKGFIYN
     GRKYPTKPQG DTYKIAHRIF LKYYPQKTPT LR
//