ID   A0A3Q0R5L6_AMPCI        Unreviewed;      1111 AA.
AC   A0A3Q0R5L6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=StAR-related lipid transfer (START) domain containing 13b {ECO:0000313|Ensembl:ENSACIP00000005402.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000005402.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000005402.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q0R5L6; -.
DR   STRING; 61819.ENSACIP00000005402; -.
DR   Ensembl; ENSACIT00000005567.1; ENSACIP00000005402.1; ENSACIG00000004247.1.
DR   GeneTree; ENSGT00950000183061; -.
DR   OMA; CAIMKVE; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04375; RhoGAP_DLC1; 1.
DR   CDD; cd09592; SAM_DLC2; 1.
DR   Gene3D; 1.10.287.2070; -; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR12659:SF6; STAR-RELATED LIPID TRANSFER PROTEIN 13; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   Pfam; PF01852; START; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SMART; SM00234; START; 1.
DR   SUPFAM; SSF55961; Bet v1-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50848; START; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          660..866
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          912..1080
FT                   /note="START"
FT                   /evidence="ECO:0000259|PROSITE:PS50848"
FT   REGION          166..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..343
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1111 AA;  125397 MW;  9BF87BE23ECC5728 CRC64;
     MFWELPESTG SECLGSMTPE TQDIYLRMDH HRRRSGYRLG RIIARQQLLK KIAGEIEAKE
     ACDWLRAAGF PQYAQLFEDS QFPIDITPVK RDHDFLDKDL VEPLCRRLNT LNKCASMKLD
     VSLPKKKNED SDEEDLFAIS DKWTFEWSSR RWSRLRDIDS LLGNHKEGEI SRDGVPLRTT
     TSSESVLTDL SEPEVSSLHS ESSGGSGHRA LSTEDSDCSN RTCSDSAAMP DSTSVTMPHI
     PKEFAHFSSP LDKHSKTTRT RAKDLLKRMD ALSSRGTLEK GRKTLVISSP VLQDAQTLKK
     LRCEDIINGD GGAPEPPCNK ILPSHSSSEG SSHSGGSTVS TPSLKERKPH RADYKRSGMY
     LEDMDIFSGT QMNKVAEQNR RNEFCSYENL VVHIPKDHKP GTFPKALSIE SLSPTGGASI
     NWHTGSMHLD SALISCRKDT RPVTQCSTRG SRISVYDNVP GSHLYASTGD LIDLEKEDMF
     PHLDDILLHV NGLQQIVDHW SKNVLPGGEG IVEIDDGKDD TVELQSSSQI TLDFEGNSVM
     ESQIMASDGD RDKASLAETD STRLRERRDS GVGASLTRPN RLRWPSFQIS NRLSHSRASL
     QITNQSAGQL SLLQKFSLLC LTAIMEKYSM SNKHGWTWSV PKFMKRMKVP DYKDKNVFGV
     PLIVHVQRSG QPLPLGLQQA LRYLRSQCLD QVGLFRKSGV KSRIQTLRQM NESSPDNVNY
     EDQSAYDVAD MVKQFFRDLP EPLLTSKLGE TFLHIYQYVP KDQRLQAVQA AIMLMSDENR
     EVLQTLLCFL SDVTSSVDEN QMTPMNIAVC LAPSLFHLNI MKKDNLSPRA MQKKYATGRP
     DQKDLNENLA ATQGLAHMII ECNRLFEIPH EMVTQSRNSY VEADLHAPTI DELCKQLEDD
     DGTYHMHMEG RLQNLLKEAR EKSKYWVSCS SSDNTELYYK KVGDGNPLRR WRVSVEVEAP
     PSVVLNRVLR ERHLWDMDLL QWKVCETLDK QTEVFQYVLS RMPPHPSRDF VVLRSWRTDL
     PKGACSLVSV SIEHEDCPPI GGIRAIVLES NYLLEPCGSG KSRLTHICRV DLKGRTPDWY
     NKAFGHLCAA ETARIRNSFQ PLIPDGPETK I
//