ID   A0A3Q0R617_AMPCI        Unreviewed;       598 AA.
AC   A0A3Q0R617;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|ARBA:ARBA00012644, ECO:0000256|RuleBase:RU361242};
DE            EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE   AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN   Name=GALNT8 {ECO:0000313|Ensembl:ENSACIP00000005527.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000005527.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000005527.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU361242};
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU361242}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane protein
CC       {ECO:0000256|RuleBase:RU361242}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC       subfamily. {ECO:0000256|RuleBase:RU361242}.
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DR   STRING; 61819.ENSACIP00000005527; -.
DR   Ensembl; ENSACIT00000005695.1; ENSACIP00000005527.1; ENSACIG00000004351.1.
DR   GeneTree; ENSGT00940000160161; -.
DR   OMA; RWEIQNI; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd00161; RICIN; 1.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR   PANTHER; PTHR11675:SF50; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 8-RELATED; 1.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   Pfam; PF00652; Ricin_B_lectin; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF50370; Ricin B-like lectins; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|RuleBase:RU361242};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU361242};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW   ECO:0000256|RuleBase:RU361242};
KW   Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW   Manganese {ECO:0000256|RuleBase:RU361242};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361242}.
FT   DOMAIN          161..322
FT                   /note="Glycosyltransferase 2-like"
FT                   /evidence="ECO:0000259|Pfam:PF00535"
FT   DOMAIN          469..589
FT                   /note="Ricin B lectin"
FT                   /evidence="ECO:0000259|Pfam:PF00652"
FT   REGION          65..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   598 AA;  69227 MW;  26884FABFB7458E2 CRC64;
     MELERIWKEE WQRIPKSRCG KLVASFPRRL MAVLAQKGFF FFNKYAKIST FKMLEEDRAK
     QREAAEVQQP AVLKQPEKEK EDDANIQKKX SEKLFPNSAL FKEWGENLSE DDQREAQSLF
     VKYGYNVFLS DRLPLDRPVP DTRDPRCLKK SYPKDLPSLG VVLIYLNEAL SILKRALRSI
     IDRTPKNLLK EIIMVDDNSS NGRLGFKKSY CQENPNLSIL RVRHSERRGL AYARASGWRA
     ATADVVAILD AHIEVHEMWA EPLLTQIKAD RTVVVSPVFD KVNFDDLKVI HYHSAAHAFD
     WALWCMYESF SPEYYKLNDN SLPGKSPSIM GILVADRKFL GEIGLLDEGM KVYGGENVEL
     GIRVWTCGGS IEVVPCSKIA HIERNHKPYM LDLSPAMRRN ALRVAEIWMD EYKHNINVAW
     NLPFENHGID IGDISERKKL RERLKCKPFK WYLDNVYRKL DPWDNLLAYG GMKNLDADMC
     LDQGPVPGHT PLAYNCYYYG TQITYYRGTG ELYIGGIESH KYNDNRCLTD VGEKETEPGL
     YNCKEAMQKG MGIYWDFTQG KELKNRQTKR CLEIINHKLL IQECSGQRWQ IQNIIKPF
//