ID A0A3Q0R6P9_AMPCI Unreviewed; 1387 AA.
AC A0A3Q0R6P9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRT {ECO:0000313|Ensembl:ENSACIP00000005603.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000005603.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000005603.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR STRING; 61819.ENSACIP00000005603; -.
DR Ensembl; ENSACIT00000005773.1; ENSACIP00000005603.1; ENSACIG00000004378.1.
DR GeneTree; ENSGT00940000155326; -.
DR OMA; XPMQETV; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14630; R-PTPc-T-1; 1.
DR CDD; cd14634; R-PTPc-T-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF8; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 702..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..145
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 147..238
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 245..338
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 343..437
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 438..543
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 835..1089
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1009..1080
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1121..1383
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1297..1374
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 731..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1387 AA; 155533 MW; 137C8929C35676C0 CRC64;
LGTNGFTWEQ VNSWEKPTID PALPTGSFMV VNASGRASGQ KAHLYMPTLK ENDTHCIDFL
YSLSSRDGAS PGTLNVYIKV NGGAQGNPVW NASDIVTEGW VKAELAISTF WPNSYQVIFE
AVSVQGHPGF IAIDDIRVLA HPCRKAPHFL RLQNVEVNVG QNATFQCTAG GKWSQHDKLW
LQQWNGKDTA LMVTRVVNHR RFSATVSVGD TSQRSTSRYR CVIRSDGGSG VSNYADLIVK
APPTPIAPPE LLAVGATYLW IKPNANSIIG DGPIILKEVE YRTTSGNWAE THVVDAPTYK
LWHLDPDVEY EIKVLLSRPG EGGTGPPGPP LVTRTKCADP VHGPQNVNVV DVRARQLTIQ
WETFGYAVTR CHSYNLTVQY QYVFNQQEFA AEELIQTSSH YTLRGLRPFV TVRLRLVLAN
PEGSKESEEI VKQTEEDVPG SVPMESLQNT PYEEKIFMQW KAPNETNGII TLYEITYKAL
SSLDPSADLT TQRGRVFKLR NETHHLFVGL YPGTTYFFTL KASTNKGFGP PVTTRISTKI
AAPMMPEYES ESPLNETETT ITILLKPAQS RGAPISSYQL VVKEERKSKT RRAASEAPEC
FSVPVSFRNA SILDSPYYIA AELPPSSLTV VQPFTVGDNK SYGGFWNPPL SPAKSYSIYY
QAMSRANGET KINCVRLANK GASTQDSDAM EPEKQVDSTV KMAGVIAGIL MFIIILLGVV
LTFKRRKLAK KQKETASSST QQREMGPVTT ADKSTTKVST LHKDDPFSTS NQDLNGFNSS
QPSLAQPSLT LQSFPYGGCE SVEISYQSGQ FQPAIRVADL LQHITQMKCG QGYGFKEEYE
ALAEGQTAPW ETAKKDENRN KNRYGNIIAY DHTRVRLQLL DGDPHSDYIN ANYIDGYHRP
RHYIATQGPM QETVRDFWRM VWQENSASIV MVTNLVEVGR VKCVRYWPDE TEVYGDIKVT
LIETEPLAEY VIRTFTVQKK GHHEIRELRQ FHFTSWPDHG VPCYATGLLG FIRQVKFLNP
PDAGPIVVHC SAGAGRTGCF IAVDIMLDMA ENEGVVDIFN CIRELRSQRV NMVQTEEQYV
FVHDAILEAC LCGNTAIPVC EFRAIYYNIS RLDPQTNSSQ IKDEFQTLNI VTPRVRPEDC
SVGLLPRNHD KNRSMDVLPA DRCLPFLISV DGESSNYINA ALMDSHKQPA AFIVTQHPLP
NTMGDFWRLV FDYNCSSIVM LNEMDAAQLC MQYWPEKNSC CYGPIQVEFI SADIDEDIIN
RIFRICNMAR PQDGYRLVQH FQFIGWPAYR DTPLSKRSIL QLVRRLAKWQ EQYDGGDGRT
VVHCLTGGGR SGTFCAICSI NEMIQQQNIV DVFHTVKTLR NNKTNMVETM EQYKFCYEVA
LEALNSF
//