ID   A0A3Q0R8L4_AMPCI        Unreviewed;       827 AA.
AC   A0A3Q0R8L4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=IQ motif and Sec7 domain ArfGEF 2a {ECO:0000313|Ensembl:ENSACIP00000006397.1};
GN   Name=IQSEC2 {ECO:0000313|Ensembl:ENSACIP00000006397.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000006397.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000006397.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRAG family.
CC       {ECO:0000256|ARBA:ARBA00006248}.
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DR   AlphaFoldDB; A0A3Q0R8L4; -.
DR   STRING; 61819.ENSACIP00000006397; -.
DR   Ensembl; ENSACIT00000006586.1; ENSACIP00000006397.1; ENSACIG00000005009.1.
DR   GeneTree; ENSGT00940000159667; -.
DR   OMA; MSVSHRV; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
FT   DOMAIN          410..602
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..319
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  91426 MW;  D28A62B42F5D1899 CRC64;
     CPEALTFSDS SPISPPSPAS LTWAQRSRHQ PASLALRKQE EEESKRCKAL SDSYELSTDL
     QDKKVEMLER KYGGPFVSRR AAKTIQTAFR QYRMNKNFER LRSSASESRM TRRIILSNMR
     LQEEDYRQCA WRNTTTSSRR AAGRTGGGGG RGGAGGGASM HEDSTATSFS DVTLYMDEGC
     LPSSPLSRPA SSSDTEYWGG GGGGSAGGRE DSRETEGGSN TSRRSSTPCT ECRGEYRGRG
     GGGGHLPVLT IEPPSDSSVD MSDRSDERGG GGGGSSEAES PQGTIKHKPN GQPPSSPLPS
     PVPPLTPLSP LPPPLTPSPL SSSSSALQNM EAQQQHHAHL PHLHHHHLLC SDGDNESVNS
     TTTNSNDDTT VNNCSSGSSS RDSLREPIGG ATLGKQTYQR ESRHSWDSPA FNNDVVQRRQ
     YRIGLNLFNK KPEKGIQYLI ERGFVSDTPV GIARFILERK GLSRQMIGEF LGSRQQFNKD
     VLDCVLDEMD FSGMDLDDAL RKFQAQIKVQ GEAQRVERLV EAFSQRYCVC NPVLIRQFQN
     PDTIFILAFA IILLNTDMYS PNVKPERKMK LEDFIKNLRG VDNGQDIPRD LLVAIYGRIQ
     KWELRTNDDH VSQVQAVERM VVGKKPVLSL PHRRLVCCCQ LFEVPDPNRA QRSGVHQREV
     FLFNDLLMVT KIFQKKKTSV TYSFRQSFPL VDMQVHTFQN TYYPHGIRLT SANPGGERKV
     LIVFNAPSQQ DRARFTSDLR ESIAEVQEME KYRVESELEK QKGVMRPGML TGGGPGGMGV
     VNGTLGRPSL DDTYASVDGL KRTALSSSLR DLSETGEGRW TVQGSHS
//