ID A0A3Q0R8V6_AMPCI Unreviewed; 893 AA.
AC A0A3Q0R8V6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5C {ECO:0000313|Ensembl:ENSACIP00000005470.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000005470.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000005470.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; A0A3Q0R8V6; -.
DR STRING; 61819.ENSACIP00000005470; -.
DR Ensembl; ENSACIT00000005638.1; ENSACIP00000005470.1; ENSACIG00000004303.1.
DR GeneTree; ENSGT00950000182815; -.
DR OMA; CECQAWS; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 337..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 136..217
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 493..627
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 893 AA; 99382 MW; 8B702FAAD4406AA0 CRC64;
DDDFLSLSEL PETFPSDPPE PLPHFLFEPE EGYIVKNKPV NLYCKATPAT QIYFKCNSEW
VHQKDHTVEE RVDENSGLVV REASIEITRQ QVEELFGPED YWCQCVAWSS AGTTKSRKAH
VRIAYLKKSF EQEPLGKEVS LEQEVLLQCR PPEGIPAAEV EWLKNEEIID PAEDRNFYIT
IDHNLIIKQA RLSDTANYTC VAKNIVAKRR STTATVIVYV NGGWSTWTEW SPCNSRCGRG
FQKRTRSCTN PAPLNGGLPC DGQAIHKLPC TTLCTVDGVW TEWSKWSACG TECTQWRRRE
CNPAPKNGGK DCEGLVLQSQ NCTDGLCMQT APSTDDVALY VGIVIAVIMC LVISVIVALF
VYRKTHRDFD SDIIDTSALN GGFQSVNIKT ARSADLLTAP PDLTNAAAMY RGPVYALHDV
SDKIPMTNSP LLDPLPNLKI KVYNSSGLVT PQDDLGGDFT SKLSPKVTHS LLDNSDTMNL
RNQSLARTRD PSCTAHGSFN SQGGHLIVPN SGVSLLVPAG AVPQGRVYEM YVTVHRKDSL
RPPVEDIQTV LSPVVSCGPP GALLTRPVIL TIHHCADNVQ EDWLIQLKNQ LAMGEWEDVV
VVGEENFTTP CYVQMDSEAC HILTETLGTY CLVGQSIGKA AAKRLKLAVF GPVSCTTLDY
HIRVYCLDDT QDALKEVLQM ETQMGGRLLD EPKTLNFKDS THNLRLSIHD VPHTHWKSKL
IAKYQEIPFY QVWSGSQRTL HCTFTLERLS PATTEISCKL CVRQVEGEGQ IFQLSNTLEE
EVHCIDTSLM DPASNITTLV GPNAFRIPLS IRQKLCGSLD APQTRGNDWR MLAHKLNLDR
YLNYFATKSS PTGVILDLWE AQHFPDGDLN ELATVLEEMG RHDSSLASMT TEH
//
