ID   A0A3Q0RBF1_AMPCI        Unreviewed;       952 AA.
AC   A0A3Q0RBF1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000007921.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000007921.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   STRING; 61819.ENSACIP00000007921; -.
DR   Ensembl; ENSACIT00000008157.1; ENSACIP00000007921.1; ENSACIG00000006171.1.
DR   GeneTree; ENSGT00390000011669; -.
DR   OMA; CERCVWT; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd22095; F-box_FBXO18; 1.
DR   CDD; cd18786; SF1_C; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          162..216
FT                   /note="F-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50181"
FT   REGION          19..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   952 AA;  107937 MW;  C6414D060357D3B9 CRC64;
     MCGFPGKAKR RHLNAEECDG LGQSAQGTDV LTQPHTFNQR MRNRNPNWGL YPRTPTKRPK
     FGNLDEDDDI SLLAVPLAPE LRGKEDEEID DSLFAAVMMP EPQADEEEEI DDDSLLGMTA
     EMFGNDDEFD QCDIHNEEEE VEALPDAHYG LLGSSNALLK PQGCMDDLPE EVLREVLCLI
     PAQDLYRNIS LVCHRWRNIV EDETFVPFKK KYYRYMMTER QTVLEVFSIL KSSGVTDSAS
     SDHSIRNLMA QHKVGERVRP EDVLERVKKH RLFPQAEXSI RLFGVYGVSA SDFQGVNPYA
     AMAVILILSE SVGDVQALVS LLMGCMSHLA ITEYLCHMAM MLLSLERNKI TVSNRLHYNI
     YYVLHLMENG PFPVSCPQSR QPQFHLTQEQ QQILSHNIQD DHVVKIIAFA GTGKTTTLVK
     YAEQRPHLRF LYVAFNNSVA SEARRRFPSN VDCKTVHSLA YHDVGKRYKF HEKLATRLNP
     FTISYVLPSG RGGFTKAKVV MTTLNAFMAS ADQTITVDHV PSSHVTHKVM YNGLVVHDAQ
     RIWNKMKDLN EKSKEAYYMI HDGYLKLWQL SDPKPCLSDV YNALFIDEAQ DCTPAIMDVL
     LSQRCGKILV GDPHQQIYTF RGAVNALNYV EHTHIYYLTQ SFRFGAEIAY VGATILRVCK
     GVQKILVGGK QKGKTAILSR CNFGVFSEAV HLTDANPNCR LHFIGVSVPP SDNNVEFSLL
     SDFKDRLIRS FVRRNENPFY ALKKYVEQTE DNDLHAKLTI VETYRKRIPE LVSRLKACSQ
     SDFHDADFIV GTVHKAKGLE FDTVMVTDDF AKVPCSKHNL RHNPDFSFAK IPDDEWNLLY
     VAVTRAKTTL IITKNILRII TMAGEYFLKS EMPSSLLKSD QPLPCSIANC PNCVTPGSTD
     WLAQGGPLCE RCIWTRIGPI AFLMTDDVLS MAEIPQRLDL PVHHAFFLEL FF
//