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Database: UniProt
Entry: A0A3Q0RDS1_AMPCI
LinkDB: A0A3Q0RDS1_AMPCI
Original site: A0A3Q0RDS1_AMPCI 
ID   A0A3Q0RDS1_AMPCI        Unreviewed;       189 AA.
AC   A0A3Q0RDS1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000008686.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000008686.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC       tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004903}.
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DR   AlphaFoldDB; A0A3Q0RDS1; -.
DR   STRING; 61819.ENSACIP00000008686; -.
DR   Ensembl; ENSACIT00000008946.1; ENSACIP00000008686.1; ENSACIG00000006689.1.
DR   GeneTree; ENSGT00940000165661; -.
DR   OMA; RDNQLPW; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR48069:SF6; DIHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   4: Predicted;
FT   DOMAIN          4..186
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
SQ   SEQUENCE   189 AA;  21674 MW;  C2D39700489B69A2 CRC64;
     MARILNGIVA VCPDLGIGNN GNLPWHPVRL SKEFAHFRKM TSTPSVKGKQ NVVIMGRKTW
     YSIPEKNRPL NNRINIVLSR ERKMPPAGAH YLASDFSSAL RLVDTELAEQ ADQVWVIGGS
     SLYKELMDSP GTRRLFVTRI LKQFECDTFL PEISLDKYRL LPEFPDVPHE LQEENGIQYR
     FEVYESIQE
//
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