ID A0A3Q0RE77_AMPCI Unreviewed; 644 AA.
AC A0A3Q0RE77;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 2 {ECO:0008006|Google:ProtNLM};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000008467.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000008467.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 61819.ENSACIP00000008467; -.
DR Ensembl; ENSACIT00000008719.1; ENSACIP00000008467.1; ENSACIG00000006536.1.
DR GeneTree; ENSGT00940000163863; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd20314; DSRM_EIF2AK2; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR PANTHER; PTHR11042:SF163; INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 6..72
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 191..260
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 352..628
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 381
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 644 AA; 73947 MW; FA8C3AD31ABEAC3A CRC64;
MAQTKNYIAE LNEHAQKNHL KLRFEDLGSD GLDHNKIQKV IIDGKDYPKG VGKTKKDAKL
KAAENALRCL LDGQDLTENA AEASAPVKTD INYICWLNEY GQRNRLTVKP VESTRPGPHN
IIPWCSFMVG DEEYPAVSGK TAREAKEEAA KLVYDMICGN KATDTADENR SYAAGQQINH
SGSDSRLAQE NYIGLVYDYC QKKNNGLPRF IEDNICGTPD KRQFFYKLMI DDKEYPVGKG
RSIKEAKQNA ARLAWSLLQG QAGEVLIFFY PPFVCSFKSH LKRSLDKLVL LRSGWMSLFL
KRIQLIRAHF RCFNPFMLLF SKDAVQDKNV GNSQTEGSTV SRVTVCRFTS EFEPLERLGK
GAFGSVHKVR HKKLNKEYAV KIVCYKEKAL REVSALSDLF HRNIVRYYTF WEEDTRYEGD
LSFDSYSSSH TADNSEAKFL YIQMELCAEN TLKDWIDEKN DQGLQDSKRR EESLRIAQEI
VCGVEYIHSK NHIHRDLKPA NIMFGMEGEV KIGDFGLVTS DDDDDAWIER TVCKGTPSYM
APEQKSERQY DRKVDMFALG LIFFELLWKL STRSERAMIW PDXRKQNFPE EFSVMFXKEK
QIINSLLCEK PEDRPDAGAL KAALEEWTQI YNGQKSFHQE NQTV
//
