ID A0A3Q0REJ7_AMPCI Unreviewed; 1258 AA.
AC A0A3Q0REJ7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=G protein-coupled receptor 158b {ECO:0000313|Ensembl:ENSACIP00000010644.1};
GN Name=GPR158 {ECO:0000313|Ensembl:ENSACIP00000010644.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000010644.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000010644.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic
CC cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3Q0REJ7; -.
DR Ensembl; ENSACIT00000010951.1; ENSACIP00000010644.1; ENSACIG00000008292.1.
DR GeneTree; ENSGT00940000155918; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF27; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..610
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1040
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1090
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1258 AA; 141945 MW; A49833E1FB266B07 CRC64;
MGRSLPRHLP LPWQRPASHP GRTQAGLRWT PTERTVVAHK IEEDLPRVVT AFLHTGDSSA
LRQVNCSRRY ELSSLRGGLH VASHYSLHSI LDTVAHATNF LNMILQANRS REQTLRRDIH
WYHALVQSIL EGDPKIHRAV VTLHTDAPTP GPHVFLQATR TENEVVLQDL SNSAHRHLKG
RSPETDWFNE FRDGRRPHMH RRITEVSGSK SGTYLLDKNQ IKWSAPYLEC EHGTFVPYWL
LTLSAGFYGL KSNFAPEFRG VVRVDVNLQD VDIDQCSNSG WFGGTHRCNL TSMECTPIVG
HGFVLDKYKC QCRRGFYHPS RVPGPDEQYN HSTAVCLPCR AGCPYCRDDT PCLVQEDGAL
RLSVASFQGL CMMLDLASMV VVYHFRRNKS IRTSGLILLE AILFGALLLY FPVMILYFNP
SVFRCILLRW VRLLGFAIMY GTIILKLYRV LKVFLSRTAQ RTPYMTSWRV LRLLAVILLV
VLWFLVAWTS SVCQNRELSR ALIAAGLTPE GLQFSMCLLD RWDYMMAVAE FLFLLWGVYL
CYAVRTVPSA FHEPRYMAVA IYNELLISAI FHIIRFSLVP GLHPDWMLML FFAHTHLTVS
VTLGLLLIPK FLYKGTQARD DIATEAYEEE LDMGRSGSYL NNSITSAWSE HSLDPEDIRD
ELKKLYAQLE VYKCKKMLAN NPHLQKKRNS KKGLGRSLMK RITEIPETMH IHRQCSRDDG
SEHGSNRSTL RRNPFEPSHH GKPRDDSLKN KVMGLKKSLS YDHVCDQDEE SGSQTVSAAG
DKTTPAGSGG EGSLLGSLIG RKHAKKQLEP AATPPRLEPA ESTESVPLFW KSASAHNLTH
EKKPVHLRTS IMQKSLSVIA SAKEKMPGLT NKTQSVEDAS KKCVKSQEGR MLSEVDETPE
HYPKMPVSQS VEYSKTPMKM GIMKQQVLFY IITFLIDIDL PSICSETGRN LYNVSEVCSW
ELEEPQTPSE AKTQKHVSIA PGETTSGRRG SSSSSGITKG GRSQQRQKTG QSPSNRRRAK
DKGGEREEGR ETRKSRPPRS PLPLKPDVCP WEFDEQPMLK GDSDSISPDR IRRKKSVTPT
DGKPKGLHSD HSKSTGSLLQ PPSLMVEICP WDYTSPPSPK QEKTCNSPTT HKKKRKGSSS
SNHKAEKEKG REKSRERRSS SSKPPSERRR VSQSSECSGL APERRRSSTK DPEMMEIRRA
EVFSQETEHS HASLAQTRKS PEKKKEGSLS SSYKPAVVSG AKRVDVCPWD FQDSGERA
//
