ID A0A3Q0RGF1_AMPCI Unreviewed; 897 AA.
AC A0A3Q0RGF1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC3 {ECO:0000313|Ensembl:ENSACIP00000009661.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000009661.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000009661.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR STRING; 61819.ENSACIP00000009661; -.
DR Ensembl; ENSACIT00000009948.1; ENSACIP00000009661.1; ENSACIG00000007566.1.
DR GeneTree; ENSGT00940000157538; -.
DR OMA; AKACFTR; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44395; -; 1.
DR PANTHER; PTHR44395:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC3; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 259..330
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 446..479
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 563..596
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 597..630
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 825..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 100879 MW; 53E1CA3626B51736 CRC64;
MAVVSWKEIL LLTGLVVGCY WNGLSCGFVF DDVSAILDNK DLRPSTPLRS LFLNDFWGTP
MAEERSHKSY RPLTVLTFRL NYLFSELSAA SYHLLNVILH AVVCVLFLRV CRSFLDKTSS
LVAALLFAVH PIHTEAVTGV VGRAELLSSI FLLAAFLAYT KSTGPDHSIV WAPIALTVVL
VAAATLCKEQ GITVIGVCCV HEIFVAQXFT LPMLLDTIWQ VLQGKDGFPY AVLQTLLKLI
VLVISTLLLV IIRVQVIQSQ LPVFTRFDNP AAVSTTPTRQ LTFNYLLPVN AWLLLNPSEL
CCDWTMGTIP LVESLLDLRN LATLVFYIFL GRLAYHSLRY RHSSAKTVIM ALSLIVLPFI
PASNLFFPVG FVVAERVLYV PSMGFCVLVA HGFKMVSHKG QLKKISWLMI GVLLTTHAVK
TFHRNWDWES EYTLFTSALK VNKNNAKLWN NVGHALENQN NYAKALRYFL QATRVQPDDI
GAHMNVGRTY KNLNKSKEAE DAYLVAKSLM PQVIPGKKYA TRVAPNHLNV YINLANLIRA
NDSRLEEADQ LYRQAISMRP DFKQAYISRG ELLLKMNKLT EARDAYLRAL ELDRTNADLW
YNLAIVNIEM KDPSEALKNF NHALELNPRH KLALFNSALL MQESGEPKFW PEANRRFLIY
VEEEPDDANG YFNLGMLAMD ANENAAAERW MRKAIGLQAG FRSALFNLAL LYSQSKREVD
ALPVLDELLR HHPEHIKGLI LKGDILMNHK KDTQGAKACF ERILGMDPTN VQGKHNLCVV
YFEERDLPRA ERCLEETLAL APNEEYVRRH LSIVRSKMAA MSAAGQPLSS ATTEGATTSS
KEEVVRGVGV DQSKSLDSSQ SDKQTKVKST KDIKDIEKKR EAALKRLEEI ERILSGD
//
