ID A0A3Q0RJE7_AMPCI Unreviewed; 911 AA.
AC A0A3Q0RJE7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Toll-like receptor 22 {ECO:0000313|Ensembl:ENSACIP00000010666.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000010666.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000010666.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR Ensembl; ENSACIT00000010973.1; ENSACIP00000010666.1; ENSACIG00000008143.1.
DR GeneTree; ENSGT00940000163999; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..911
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018526176"
FT TRANSMEM 697..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 749..890
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 911 AA; 104723 MW; 6CA9DA637B006757 CRC64;
MEFCSFSLFR CFVIFLYTEN TNNVSVTCAE RYLTAIPDDI PRNAISLNLN SNLISNITRT
DFGGLSKLEA LHAKNNFILK IDDGSFADLV ELKVLILGEN IFTNVTENMF QGLSKLETLS
LYGNQISFIS PVAFQPLVSL XSVDLSYNAL HQITDIEQII KLPTLQYLDI SSNRFSYFQT
DDFHVNTSNL DIFPLLQSLN LQHCTIDIEW DVSSKTFLKS LMRLYLSETS ISFEVYRAIL
QTADSLQDLQ MYKMKKWIDE GLIDIACQIP SLRTLEVNYN EIYTINDDLL QSCSHLTELN
LSFNMLSGMA DNALQSMTQL RCLILQNNHL SEVPLAVQGL TTLEVLDLSN SDISDFYGPE
FSSLTNLTIL HLSHNRISYI FECVFENLNN LKVLNLENNE ILSFDNTFKD ILQELEFLNL
RNNDIIDLSQ GDLSNLSSLH YLDLDLHQCI SVDEGGFEGL YNLQTLFLLG DDYFYKHFRG
LTNLKTLTLN VVCSLTHNSS QQRDDPFSDL PKLKKLVIDV QKGFCATISK DVLSGLTSLE
YLMTEAYFMG SLHTDTFKYT PQLRGLKITY SELSDLTSEV FLPIPHLKML DLSNNKLRSL
AFLAEARLLA LRQLNVSNNE LFIISETVIQ SLPTLTYLDL TANPLTCECS NYGLIQWIQS
SKQTQVVNEH QYTCAYPVSQ RGNKFLDFGY DSCRIDAGFL CFLFSSCLIV LTLLTSFIYH
FLRWHLTYAY YLFLAFLYDH KRRKKGSPYS YDAFVSYNVH DEAWVYGELL PVLEGQQGWR
LCMHHRDFEP GKLIVENITE AIYSSRKTIC VISRHYLQSE WCSREIQMAS FRLFDEHKDV
LIMLFLEDIP AKQLSPYYQI RSMLKKRTYL SWPQAGQHAG VFWQKIRQAL EGAEDTTEHR
HLLTGHPIVI Q
//
