ID A0A3Q0RKS7_AMPCI Unreviewed; 1040 AA.
AC A0A3Q0RKS7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSACIP00000009320.1};
GN Name=SLC12A2 {ECO:0000313|Ensembl:ENSACIP00000009320.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000009320.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000009320.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q0RKS7; -.
DR STRING; 61819.ENSACIP00000009320; -.
DR Ensembl; ENSACIT00000009599.1; ENSACIP00000009320.1; ENSACIG00000007264.1.
DR GeneTree; ENSGT00940000155742; -.
DR OMA; QDYVRCR; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF105; SOLUTE CARRIER FAMILY 12 MEMBER 2-LIKE; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..151
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 184..364
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 374..656
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 665..801
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 830..1040
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1040 AA; 114264 MW; 1F4F3604E979A9FA CRC64;
MSGQKPSLRS EGSGQSRFQV DVVMEASSSA SGPASADGSR PPEESKGRFR VVGFMDSGAL
DIGLPPDISH EPDTAKSDSV SLHSTGTGHT HISDSHSNTY YMRTFGHNTI DAVPNIEFYR
QTAAPFGEKL TRPSLSELHD ELDKVLTNTD GLANGEQPSA AEEAAALAAK EAKGGTVKFG
WVKGVLIRCM LNIWGVMLFI RLSWIVGHAG IGLTIAIILM ATVVTTITGL STSAIATNGF
VRGGGAYYLI SRSLGPEFGG SIGLIFAFAN AVAVAMYVVG FAETVVELLN DVDALMTDEL
NDIRIVGTLT IILLLGISVA GMEWEAKAQI VLLVILLAAI ANFFLGSFMP TETKEPKGFF
GYHSQSAFLS FLHKEISDPQ SAIPKGTLLA ILITGITYVA VAISTGACIL RDATGDHNDT
VSPTVNCTDA ACTLGYDFSI CKEGGCPYGL MNDFQVMSLV SAFGPLITAG IFSATLSSAL
ASLVSAPKVF QALCKDNIYP GLSVFAKGYG KNNEPLRGYV LTFCIGLAFI LIAELNIIAP
IISNFFLASY ALINFSVFHA SLASSPGWRP SFKYYNMWVS LAGAILCCVV MFVINWWAAL
VTLLIVLALF IYVSYKKPDV NWGSSTQALI YNQALTHCLN LTGVEDHVKN FRPQCLVLGG
YPNARPALLQ LVNSFTKNVS LMVCGHVRTL YQDYARCQRW LNKKRIKAFY APVFSDNLRH
GAQLLLQAVG LGRLKPNTLV MGFKNNWSDG DMRDVENYIN TIHDAFDLLF GVVILRLQEG
LDISHIQGQV KQVKYSEYDT EQERLCFFTL SHFTVVDVIS PATETKSPLS PSDQRLLESS
QQFKKKQGKG TIDVWWLFDD GGLTLLIPYL LTNRSKWGDC RIRIFIGGKI NRIDHDRRAM
ATLLSRFRID FSDINVLGDI NTKPKKHNKL TFKELIEPYR LKEDDMEQEA AERLKAQEPW
RITDNELELY KAKTNRQIRL NELLKEHSST AKLIVMSMPL ARKGTVSSAL YMCWLETLSK
GLPPLLLVRG NHQSVLTFYS
//