ID   A0A3Q0RQF0_AMPCI        Unreviewed;       126 AA.
AC   A0A3Q0RQF0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Adenosine 5'-monophosphoramidase HINT1 {ECO:0000256|ARBA:ARBA00039810};
DE   AltName: Full=Desumoylating isopeptidase HINT1 {ECO:0000256|ARBA:ARBA00042634};
DE   AltName: Full=Histidine triad nucleotide-binding protein 1 {ECO:0000256|ARBA:ARBA00042358};
GN   Name=HINT1 {ECO:0000313|Ensembl:ENSACIP00000012018.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000012018.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000012018.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+);
CC         Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:57890, ChEBI:CHEBI:456215;
CC         Evidence={ECO:0000256|ARBA:ARBA00024472};
CC   -!- SIMILARITY: Belongs to the HINT family.
CC       {ECO:0000256|ARBA:ARBA00025764}.
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DR   AlphaFoldDB; A0A3Q0RQF0; -.
DR   STRING; 61819.ENSACIP00000012018; -.
DR   Ensembl; ENSACIT00000012359.1; ENSACIP00000012018.1; ENSACIG00000009379.1.
DR   GeneTree; ENSGT00940000154451; -.
DR   OMA; LAFMDVM; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01276; PKCI_related; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR019808; Histidine_triad_CS.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR23089:SF33; ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT1; 1.
DR   PANTHER; PTHR23089; HISTIDINE TRIAD HIT PROTEIN; 1.
DR   Pfam; PF01230; HIT; 1.
DR   PRINTS; PR00332; HISTRIAD.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS00892; HIT_1; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   3: Inferred from homology;
FT   DOMAIN          18..126
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   MOTIF           110..114
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT                   ECO:0000256|PROSITE-ProRule:PRU00464"
FT   ACT_SITE        112
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ   SEQUENCE   126 AA;  13466 MW;  3FF9C8EA30645EA1 CRC64;
     MADETAKAQT AKPGGDTIFG KIIRKEIPTT LIFEDDQCVA FNDISPQAPT HILVVPKKPI
     VQLSQAEDAD AALLGHMLIV ARKCAKDAGL SKGYRIVIND GPDGGQSVYH VHIHILGGRS
     MAWPPG
//