ID   A0A3Q0RSP7_AMPCI        Unreviewed;      1002 AA.
AC   A0A3Q0RSP7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Cingulin {ECO:0000256|ARBA:ARBA00044075};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000013711.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000013711.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Probably plays a role in the formation and regulation of the
CC       tight junction (TJ) paracellular permeability barrier.
CC       {ECO:0000256|ARBA:ARBA00043864}.
CC   -!- SIMILARITY: Belongs to the cingulin family.
CC       {ECO:0000256|ARBA:ARBA00038467}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q0RSP7; -.
DR   STRING; 61819.ENSACIP00000013711; -.
DR   Ensembl; ENSACIT00000014081.1; ENSACIP00000013711.1; ENSACIG00000010611.1.
DR   GeneTree; ENSGT00940000154489; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   PANTHER; PTHR46349:SF4; CINGULIN; 1.
DR   PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054}.
FT   DOMAIN          646..956
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   REGION          73..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          607..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          958..982
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        965..982
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1002 AA;  114646 MW;  CD38EEE231FDCF3B CRC64;
     MTTPSSDRKT PVDYGVQIRF INDLYENGGV QPVTQPKTKS QTASKYGVAV RVQGIDGHPY
     VVLKDGKKGD SYGVQIKTQY SPGHNSLPRK REKADPGIEG DHVGGGGGDE DFQLSRPPGD
     GKSGSYGNLD AGIGVRGDGE QGWHVSDREG GTERNMWHGS YQSGLNRSLG SVRDSPEPPP
     QQYDLDYNKR QTSVNRLINR FGGVNAGGQQ RGLSPPQQHP RAASPPTTAN PYTLPASSTH
     SSLGRSQGTF KVPGHSANQW TSVEPPQRNL TEAQVRIQSF VTPDLLLDQG QSAELSSEEE
     QAMQTVYNIL RQGYRLPLYL PVATFAHIDN SDPALKAELE RCLDESLQLQ EMLDRKEKEL
     NETQSELTQL RMDRENAEKR VREMEDQLAE FQDELRRENS NKTDLVSCQA QLMEFCQLKK
     KLEETLRQRE RELTALKGAL KEEVATHDRE IEALREQYSA DMEKLRSSME QVSQSHAGIE
     AERLRVNASV RSLQQQLEDC RDESSHWMEQ FHSTRDELRT TNEVTQLKKK LSLTEEELDS
     SKTQLNRAHL DMNSLQDAQQ EQKEANTRLK EKISRLELQS NATESSEAEL ALHTEVRGLR
     SELDEAKRKA SRLSQEHREL GQHLEDSEKD KETLRQTISQ LEDTKRQQER ALEKLNKENE
     SVNMSLREEA QALRVQLDEQ KERARKEMQE AQRHGNDAQS ELERSQINIR KLEEEISRQK
     KELLLACEER DNHQLDKELL TNRLRHLEGE LEASKNSHSE KTREIRILED KLKRLELEVE
     EERSSVDMLT ERVARSRDQI DQLRSELMQE RSSKQDLELD KNAMERHLKE LRSRVADMEG
     QSRSSAGVSQ LENKIQELEE RLRSEEREKN AVLATQRRLE RKLKDLNMTL DEERQTHTEQ
     RDQLALRVKA LKRQVDEGET ELERLDGLRR KAQRDLEEQM ELKEALQARV TALETELKRK
     TQAAMRPTLD SSALSSDDDD SLYDPSTITS ILTESNLQTS SC
//