ID   A0A3Q0RVK7_AMPCI        Unreviewed;       643 AA.
AC   A0A3Q0RVK7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=REL proto-oncogene, NF-kB subunit {ECO:0000313|Ensembl:ENSACIP00000013733.1};
GN   Name=REL {ECO:0000313|Ensembl:ENSACIP00000013733.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000013733.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000013733.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q0RVK7; -.
DR   Ensembl; ENSACIT00000014103.1; ENSACIP00000013733.1; ENSACIG00000010598.1.
DR   GeneTree; ENSGT00940000158732; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd01177; IPT_NFkappaB; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR033926; IPT_NFkappaB.
DR   InterPro; IPR000451; NFkB/Dor.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR030492; RHD_CS.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR   PANTHER; PTHR24169:SF4; PROTO-ONCOGENE C-REL; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR00057; NFKBTNSCPFCT.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS01204; REL_1; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   4: Predicted;
FT   DOMAIN          27..204
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
FT   REGION          575..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..610
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..643
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  72607 MW;  926673DCF8F9B4E6 CRC64;
     MCTYIISVTF SSPVLMPAML GDDTRLMAEP AIQIFEQPKQ RGMRFRYKCE GRSAGSIPGE
     KSSDNNRTYP SLQILNFSGK GKVRVYLVTK NEPYRPHPHD LVGKDCKDGF YEAEFGPERR
     VIAFQNLGIQ CVRRREVKDA IIQRITRGIN PFNVPREQLL QTEEYDLNVV RLCIQVFLQD
     ENGHYTRALN PIVTNPIYDN RAPNTAELRI CRVNRNSGSV KGGDEIFLLC DKVQKDDIEV
     RFFSSDGWEA KGSFSQADVH RQVAIVFKTP PFHITSITDS VTVHMQLRRP SDQEVSEPMD
     FRYLPDDKDP YGYNEKKRRR EHLMKISGLS GGSFSGLTMN RPKAVPQSTM SHMKRDLGNA
     YPRQNASTMQ QQPSMFNQPY QQGPQNVMMT SQASNLQIRH SWANPNPRLS MDTVTVNQGP
     ISNLSHPNVS RQQQSTRGYQ HRMDHSSCEN NALPQLSIRD LQCLDTGSQV PVMRESEPLF
     HQQNQREELV SETQTQAQNH LGSQNQGIQS VWPNFTTIGT VQNPFNGPGG GGGSQGLGSF
     PFLEGIDGDD FLKNMVGGSQ PSFQLKQEPQ ITMGQESHTP LMQSPRESQG NTYTNLLPRA
     ISNGTNRDPM RQDGKNPHNP YANNGMAPET HFSTLEDWIN QND
//