ID A0A3Q0RYN1_AMPCI Unreviewed; 910 AA.
AC A0A3Q0RYN1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Alpha-actinin-1 {ECO:0000256|ARBA:ARBA00018384};
DE AltName: Full=Alpha-actinin cytoskeletal isoform {ECO:0000256|ARBA:ARBA00041477};
DE AltName: Full=F-actin cross-linking protein {ECO:0000256|ARBA:ARBA00043249};
DE AltName: Full=Non-muscle alpha-actinin-1 {ECO:0000256|ARBA:ARBA00042871};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000015567.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000015567.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm, myofibril, sarcomere, Z
CC line {ECO:0000256|ARBA:ARBA00004216}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
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DR AlphaFoldDB; A0A3Q0RYN1; -.
DR STRING; 61819.ENSACIP00000015567; -.
DR Ensembl; ENSACIT00000015979.1; ENSACIP00000015567.1; ENSACIG00000012070.1.
DR GeneTree; ENSGT00940000155548; -.
DR OMA; CYEGVEV; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF434; ALPHA-ACTININ-1; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13405; EF-hand_6; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 49..153
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 162..268
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 764..799
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 805..840
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 283..310
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 448..482
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 910 AA; 104025 MW; 0E518C47B89A7DBD CRC64;
PALPRAPEHL KVPGSVDHST ARGGGGHVTV QVAARLDCVS LPNSTVTQRL RETTFTAWCN
SHLRKAGTQI ENIEEDFRDG LKLMLLLEVI SGERLAKPER GKMRVHKISN VNKALDFIAS
KGVKLVSIGA EEIVDGNAKM TLGMIWTIIL RFAIQDISVE ETSAKEGLLL WCQRKTAPYK
NVNIQNFHIS WKDGLGFCAL IHRHRPELID YGKLRKDDPM TNLNTAFDVA EKYLDIPKML
DAEDIVGTAR PDEKAIMTYV SSFYHAFSGA QKAETAANRI CKVLAVNQEN EQLMEDYEKL
ASDLLEWIRR TIPWLENRMP ENTMQAMQQK LEDFRDYRRL HKPPKVQEKC QLEINFNTLQ
TKLRLSNRPA FMPSEGKMVS DINNAWGNLE GAEKGYEEWL LNEIRRLERL DHLAEKFRQK
AAIHEAWTEG KEDMLQKRDY ETASLSEIKA LLKKHEAFES DLAAHQDRVE QIAAIAQELN
ELDYYDSPSV NARCQRICDQ WDALGALTQK RSEALQRTEK LLETIDQLYL EFAKRAAPFN
NWMEGAMEDL QDTFIVHTIE EIQGLSTAHE QFKATLPEAD KERLAILGIH NEITKIVQTY
HVNIAGTNPY TTINPQEINA KWEKVRQLVP QRDQALIEEH ARQQNNERLR RQFANQANVI
GPWIQTKMEE IGRISIEMHG TLEDQLTHLR QYEKSIVNYK PKIDQLEGDH QLIQEALIFD
NKHTNYTMEH IRVGWEQLLT TIARTINEIE NQILTRDAKG ISQDQLNEFR ASFNHFDRDH
SGTLGAEEFK ACLISLGFDI ANDAQGENEF SRIMSIVDPN RMGIVTFQAF IDFMSRETAD
TDTADQVMAS FKVLAGDKNY ILADELRREL PPDQAEYCIA RMAPYTGPDG VPGALDYMSF
STALYGESDL
//
