ID A0A3Q0RYR0_AMPCI Unreviewed; 735 AA.
AC A0A3Q0RYR0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Mitofusin 2 {ECO:0000313|Ensembl:ENSACIP00000017739.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000017739.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000017739.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
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DR AlphaFoldDB; A0A3Q0RYR0; -.
DR STRING; 61819.ENSACIP00000017739; -.
DR Ensembl; ENSACIT00000018219.1; ENSACIP00000017739.1; ENSACIG00000013827.1.
DR GeneTree; ENSGT00390000013727; -.
DR OMA; WRWNSGA; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR CDD; cd09912; DLP_2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR006884; Fzo/mitofusin_HR2.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027094; Mitofusin_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10465:SF1; MITOFUSIN-2; 1.
DR PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF04799; Fzo_mitofusin; 1.
DR SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 607..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..320
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 678..715
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 735 AA; 83431 MW; 7ED14771ED73968B CRC64;
MAEVNASPLK HFVTAKKKIN GIFEQLGAYI KESASFLEDT YKNEELDPVA TEEQVQEVRG
YLAKVTGIGE VLARRHMKVV FFGRTSNGKS SVINAMLCDK VLPSGIGHTT NCFLRVEGTD
GNEAFILTEG SEERKNIKTV NQLAHALHQD EDLDAGSLVC VMWPKAKCAL LRDDLVLVDS
PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKSF FHKVNERLSS PNIFILNNRW
DASASEPEYM EEVRRQHMDR CTNFLVDELG VVDRAQASDR IFFVSAKEVL QARVQKAQGM
PEAGEDISLC KIFLKKIKTK TRRECISQSA VKTKFEQHTV RAKQISETLR RIMDSVYVAA
QEQRVYCLET KEDRQDRLEF IDKQLDLLTM DCKAKIKKIT EEVERQVSNA MAEEIRKLHV
LVDDFHMDFH PSLVVLKVYK NELHRHIEEG LGKNMSERCS TSITSALQAT QTDMIEGLKP
LLPSTVREQV DKLVPRNQCF SLSYDLACDK LCMDFQEDIS FHFSLGWTML VNRFLGPKNT
RRVLMGYSDQ VPRPMALTPV STSMPPFPQS SMTQEELMVS MVTGLASLTS RTSMGVLVVG
GVIWKAVGWR LIALSVGLYG LLYIYERLTW TTKAKERAFK RQFVDYASEK LQLIVSYTGS
NCSHQVQQEL AGVFAQLCQQ VDITRQNLED EITDMNSKIE LLDSLQSKAK LLRNKAGWLD
SELNMFTQQY LHHSK
//
