ID A0A3Q0S0Y7_AMPCI Unreviewed; 1021 AA.
AC A0A3Q0S0Y7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Si:ch211-26b3.4 {ECO:0000313|Ensembl:ENSACIP00000018534.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000018534.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000018534.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR STRING; 61819.ENSACIP00000018534; -.
DR Ensembl; ENSACIT00000019032.1; ENSACIP00000018534.1; ENSACIG00000013865.1.
DR GeneTree; ENSGT00940000164237; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01260; PH_CNK_mammalian-like; 1.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR010599; CNK2/3_dom.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF12; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2; 1.
DR Pfam; PF06663; CNK2_3_dom; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
FT DOMAIN 11..76
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 84..190
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 192..261
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 530..638
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 291..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 114731 MW; 45A6F8AA643786A6 CRC64;
MALVMEPISK WTPKQVLDWM KGLDDCLQQY IKSFEREQMG GEQLLHITHQ ELEELGVTRI
GHQELILEAV DLLCALNYGL ETENLRTLSH KLNASAKNLQ NFILGRRRGG HYDGRASRRL
PNDFLTSVVD LIGAAKNLLA WLDRWVPYHM NLRMLKSPFA SVTEYSLLKN NIVQLCLELT
TIVQQVLSHC SGMYIKSTYD GLHVITGTTE NSPADQCKKI HPGDEVIQVN HQTVVGWQLK
NLVNALREDP CGVILTLKKR PQNTLSSTPA LLRNVRWKPL GLQVNTGATH GCINPVPTSP
TSTSPTPGGT LGMSKMDAPS MQDVYILSPV SGLYSTREEM GLMSCDDISR YSVSSQSGSK
GSEAISYYLD QDSGQYFSLL EGDGPPGPDY DRGRNTGVRR RDKTPTHGKM MSVSRNGSGH
VFVMQKRKKX MVSSTNSDNS LLRYLSDDKI LVIEEEPEGP GRESRRDSTR RSRRKSRNPS
SPSFPISPSM LSSTLRLDQP PEDSGSFFSP SLGSLTSASR RRISCKDLGH GDCEGWLWKK
KDAKGYFTQK WRKYWFILKE SCLYWYTNQN DEKAEGFISL PEFRIDRAIE CRRKFAFKAC
HPKIKSFFFA TDCLEEMNSS NISPVSVSWE HXXXXVCVCV CVCVCVCARA HVFIFLPDYW
SESDQDEVDG SMTLKQEGPS SLCDTYHRTP SVNSSSPFPE PKHGRHFSSE STHSHSSAED
QRGDGMGMGT GTGSTSTHSS GCRSSHRERR SWQDLIETPL TSAGLHFLQT APGESEYGGL
MGSMAGEMGF YGGLGRQGMS PERRRQATLP VRRHHAAERD RERDGPFPLE RGPYTHSHTH
RRSHKQRSQS LPRNRDPMPG KLLHTSAHME ERSEDEEAEE QAADMLEGEE GKNPLDGLEQ
LYRALEQANV TALGDPRPCS RQELRRCFTQ RARDPLLNDR LHRVRALRST LKAKESELAV
ICSLLEDPGL CSQTFREWKQ WHSELYSDIC QLSPGTNGQD DLSPLAAPLM THTHSFIETH
V
//
