ID A0A3Q0S1H0_AMPCI Unreviewed; 1236 AA.
AC A0A3Q0S1H0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Adhesion G protein-coupled receptor L3.1 {ECO:0000313|Ensembl:ENSACIP00000018704.1};
GN Name=ADGRL3 {ECO:0000313|Ensembl:ENSACIP00000018704.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000018704.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000018704.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q0S1H0; -.
DR STRING; 61819.ENSACIP00000018704; -.
DR Ensembl; ENSACIT00000019208.1; ENSACIP00000018704.1; ENSACIG00000014545.1.
DR GeneTree; ENSGT00940000155527; -.
DR OMA; NENTMIM; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0071391; P:cellular response to estrogen stimulus; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd22846; Gal_Rha_Lectin_LPHN3; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF60; ADHESION G PROTEIN-COUPLED RECEPTOR L3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 887..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 946..968
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 989..1009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1029..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1073..1096
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1102..1125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..159
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 169..428
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 506..563
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 885..1126
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 438..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 170..352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1236 AA; 138340 MW; 296D0A719402BFAD CRC64;
MWTRCLLLIS TFFSPIAIGK DIVTLISALR LYKYVRSISA NNMSISMNVS VCPVYGRAPI
PMAVVRRELS CESYPIELRC PGTDVIMIES ANYGRTDDKI CDSDPVQMEN TRCYLPDAYK
IMSLRCNNRT QCAVVAGPDV FPDPCPGTYK YLEVQYECVP YKVEQKVFLC PGILRGVYQS
EHLFESDHQS GAWCKDPLQA SDKIYYMPWT PYRTDTLTEY SSKEDFIAGR PTTTYKLPHR
VDGTGFVVYD GALFFNKERT RNIVKFDLRT RIKSGEAIIA NANYHDTSPY RWGGKSDIDL
AVDENGLWVI YATEQNNGRI VVSQLNPYTL RIEGSWDTSY DKRSASNAFM ICGVLYVVKT
VYEDDDNEGT GNKIDYMYNT DKGKEMTVNI PFPNSYQYIA AVDYNPRDNL LYVWNNYHVV
KYSLDFGNND FRPPPIIPPN RGVVPIGGGG SSSSTSRAAT TTRSPPYYTT PSNQIPDTNQ
KAGGRSPPVQ VPPAPPQPPV LPPQDFCSPM VTADISWPRT QQGQTAKQPC PVGTLGVATY
VCVAHLGHWD TQGPDLSNCT SPWVNHIMQK LRSGETAAIV ARELAEQTKG LLHPGDVPST
VRAMVQLVEL LDVQLRNLTP GGKDSAARSL TKLQKRERSC RFFTQAMVET VNNLLHPRAE
KAWRELPTSE QLHSATLLLD TVETGAFMLA DNLLKTDTVQ ETTDYIQLEV ARLSTDGNLA
DLTFPQSEQH GNSIQLSAST LKQHGRNGEI RMAFVLYKNL GSYLSTENAS VRLSSDTVYP
NYSVIVNSPV ITASINKESN KVYLSEPVVF TVKHLQHSEK NFNPNCSFWS YSKRTMTGFW
STQDCRLLAT NRTHTSCSCT HLTSFAVLMA HVEVKVTDSM HDVLLDVITW VGILLSLVCL
LICIFTFCFF RGLQSDRNTI HKNLCISLFI AESLFLVGIN KADQPIVCAV FAALLHFFFL
AAFTWMFLEG VQLYIMLVEV FESEHSRTKY FYLAGYGVPA VIVAVSAAVD YRSYGTDRVC
WLRLDTYFIW SFIGPATLII MLNVIFLGIA LYKMFHHTAI LKPDSGCLDN IKSWVIGAIA
LLCLLGLTWA FGLMYINEST VIMAYLFTIF NSLQGMFIFI FHCILQKKVR KEYGKCLRTH
CCSGKSVETS ISSSSKTTTS RTPGRYSTGS QSRIRRMWND TVRKQESSFI TGDINSSATL
NRGNHGIPTI CILITVTIST LLIAGGTDGI RCHLAK
//
