ID A0A3Q0S2K1_AMPCI Unreviewed; 1534 AA.
AC A0A3Q0S2K1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma, 1a {ECO:0000313|Ensembl:ENSACIP00000019094.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000019094.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000019094.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR Ensembl; ENSACIT00000019607.1; ENSACIP00000019094.1; ENSACIG00000014458.1.
DR GeneTree; ENSGT00940000154648; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF10; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
FT DOMAIN 1173..1295
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1368..1534
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1017..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1534 AA; 170961 MW; F2927222B511B73C CRC64;
YGPGQPASLV FATPPPPQMN SAPQPRQSYY QNRPTMAASA PRVQGNSGPR PVTATHVYQP
GSQMMMIPQQ QLPFASSTQS YFIPPGQVSA HTKLCPAATG AYYPAQPQYS PSVQPSAVML
STQQQQQAPP PQQPPAQSQG PPKRERKPIR IRDPNQGGRD ITEEIMSGGR SSTTPTPQVR
PAFGKTAPDV SPAQINGEIA QPATTPTRRG EHIKFGLVKN EEFDIFPHCC HVSHCPDENA
EHPASVETPP PCATANAEPV LESKQEVDSQ IAPPTELAAQ SVAPVATTEV PCTLIKDQQS
PPSLPPGAPL TTTPAEVVNK VSTNVGDTVD APVATSQSLA APEAPVKMEE PLAAPAQAEN
APVKEETKTE EVKKLEEEEQ VPSTKLEPAV EVAAIVSSNV EKEEMAPKTA PEVSQPPPPV
LESAAPQTQN ADLCSTPEPE STQVETAEPR KNMKELNKKE AIGNLLDAFT EVCVSSNDSP
KPLNSCEQGA KPASEPSSTQ TWEQKEDKQN AEPDKSKATP EPTEQKYQFK QEQWKPINPE
EKKRYDREFL LRCQFISASM HKPEGLPVIS DVVLDKVNKT PLRPADPARL MSAGPDFTPS
YLGNLGSRSM GGPRGLLPGP RRSQQGQRKD RKIISSMSLN DDVQLSKAEK AWKPSVKKAT
RVRSEEPEED EPEQAKTQEL FKRLRSILNK LTPQKFQELM KQVTELTIDT EERLKGAIDL
IFEKAISEPN FSVAYANMCR CLMGLKVPTS DKPGVFVNFR KLLLNRCQKE FEKDQDDDEI
FEKKQKELEA AKDDDERERF RVELEEARDK ARRRSLGNIK FIGELFKLKM LTEPIMHDCV
VKLLKNHDEE SLECLCRLLS TIGKDLDFEK AKPRMDQYFN QMDKIIKERK TSSRIRFMLQ
DVLDLRKNNW VPRRGDQGPK TIDQIHKEAE MEEHREQIKV QQQLMSKKES GGRMGGSMGG
RGPHTPGGGR VSQPQDEGWN TVPISKNRPI DTTRLSKITK PGAMDFNNQL LAPGGKGMWG
SWGKGSSGGS GAKPASGDQD SGRPATSTLN RFSALQSGSL LSSADTDRRV PQRDRSDRNR
EQFDRFDRNE GREGNQITKR SFSRESQERG GRGGDSRAST EPVRRVASMT DSRDRGSRDR
GSRDRGSRDR GTKRESVPTP PPSLPKPSLT EEEVEKKSNA IIEEYLHIND VKEALQCVAE
LNSTSLLYVF VRNGVESTLE RSTIAREHMG LLLHRLVKAG TLPTQQYYKG LQEILEVAED
MAIDIPHIWL YLAELITPML HEGGIPMGQL FREISKPLVP LGKAGVLLVQ ILKLLCKEMT
PKKVGALWTE AGLNWNDFLP KDKDVNKFVT DQNVEFTMGE EMESKEVGKK KVLTGEEISR
QLDRLLQDKA NNQRIRDWIE ANLDEQQTAS NQFVRALMTS VCQSAIICDN PYKVDAQEIS
QRASLLQRYL YDEQKELQAL YALQALMVHM EQPANLLRMF FDALYDEDVI KEEAFYEWES
SKDPAEQTGK GVALKSVTAF FTWLREAEEE SDKD
//
