ID A0A3Q0S3K9_AMPCI Unreviewed; 1030 AA.
AC A0A3Q0S3K9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Toll-like receptor 9 {ECO:0000313|Ensembl:ENSACIP00000017392.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000017392.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000017392.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3Q0S3K9; -.
DR Ensembl; ENSACIT00000017863.1; ENSACIP00000017392.1; ENSACIG00000013414.1.
DR GeneTree; ENSGT00940000163875; -.
DR OMA; NFLPCCS; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF4; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..1030
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018575080"
FT TRANSMEM 811..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 865..1013
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1030 AA; 118346 MW; 4A6B57F61D242D65 CRC64;
MLFIIFLALP LIVLTINIKF LPCDTNVNAT KVDCSDRPLR HVPFIKATSV IDVDLSRTKI
NQVGPRAFTG VPNLHTLKMS GNCQPGSLRA LEDATCKVNI FSDAFKNLLK LKYLDLSGNS
LTSIPWLPES LEVLHLENNH IFKIIQPLNT PHLEKLFLTK NCFYANPCNQ SFYISEMVFR
ELPKLKNLTL GYNNLTAIPK GLPPSLESLD LRENTITEIL EGAFANMTAL RNLNLEWNCQ
RCDHAARPCF PCPQNRSLGL YSNSFYAENS SLTYLSLRGN SLKMFPEGLF RPLKNLKRLD
LSDNLLAYAI QNGTFFDELR GLKWLSLIYN YEPRKTFPEL NLSPNFNNMS GLQYLLLSGN
FFLKLSNHSL EVLSKFQNLK VLELRMNFIN TINLTVLKQL PSLIYIDLSQ NMLNFLQCCS
SSRSGVVAQE SCQNQNSTMW EYNQLHEFPQ IPSLWDFKNV HCKNKLTFDL SQNDIVSLNK
HVVLGMENAV CLDLSFNYMN QALRGGLFEG MTNLAFLNLS YNRLDLYYND SFRELNSSLK
VLDISNNEFH FNMRGMGHRF EFLENLTQLE ALSLANNGIG MRINQRLICN PLKYFDFSGN
HLNIMWESDN NKYTHFFQNL TNLTYLDISN NHLKSLSAEV LCSLPSSLKA LSISKNLLNY
FPWINISALT SLYYLNLSHN FLYKLPDYVV AVEFGVNFTF LDLSHNRLSY IPEDFFKEAK
SLKYFYLSHN QIKELNQGHL PVLFKNGTAL QNLTLHANPF KCDCNTSWLA EFLSTTSIHI
PYLTTGVRCE FPESQQGESI LSIDQHSCQD IYGSLAFLVC SFMAVVFTVL PLLKHLYGWD
MWYCLQVLWA GHKGYSQLAG TDSQYHYDAF VVFDTSNQAV RDWVYNELIV NLENSGHRRF
GLCLEERDWI PGLSCIENLH NAVHRSVKTV FVLSRGVNGN VTVNGVIRQA FFMVQQRLLD
EKVDVAVLVL MDKMFPKLKY LQLRKRLCRK SVLSWPSHPC AQPLFWNQMR MALSSDNLKF
YDNNMSESFL
//
