ID A0A3Q0S5U2_AMPCI Unreviewed; 1191 AA.
AC A0A3Q0S5U2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000018381.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000018381.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 61819.ENSACIP00000018381; -.
DR Ensembl; ENSACIT00000018875.1; ENSACIP00000018381.1; ENSACIG00000014322.1.
DR GeneTree; ENSGT00940000162544; -.
DR OMA; SHCLPAN; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF12; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4 ISOFORM X1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 8.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1191
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018667743"
FT TRANSMEM 1126..1146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1167..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 526..569
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 570..612
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1079..1115
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1042..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 54..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 93..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 132..147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 152..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 159..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 171..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 192..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 211..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 253..268
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 273..285
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 280..298
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1105..1114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1191 AA; 129016 MW; C3F493B049C3FA22 CRC64;
MGGCLFLCLA LLSGFLQVSV GPSKPSTSSN PIKCSLGFTP CSDNTECIQN NYFCDGETDC
RDGSDEAKCS SSCERDQFQC AHGKMCIEKS QVCDGVAHCQ DRSDELECNK HMEGCSHQCD
DKSSCIPSSF LCDGEKDCAD GSDESDCDKE DCSGTEFKCI SGQCVSATMR CDGHPDCRDR
SDEEDCTKVS ACNTKLSCPQ SNECLVQEWI CDGDQDCKDG TDEKDCPVAP VNCGEFQWLC
KSKTMCISTA WMCDGMKDCN DGSDETECQV ATCAPHQFQC GSQECLDPTL VCNGITNCAD
GSDEGGSCQM NCAEADNTRC SQDCYKTPQG PRCHCAAGFR LMEDGLTCAD IDECDVQTPS
VCSQLCINTP GSYKCDCQLG FIMEADGHHC KITGEPFLLS SVQTDIYMYG LRSGSLVMLP
SSAKKAILSL DYDWKGQKVF WVSLDADAVM WSSLDQNMTG TLIKGVRADS IAVDWLGRNL
YWINGVKSHI AAIKLATVSA RSLDQSIILD EDLDQPRSLA LLPHKGLMFW TEIGNVVKIE
RAGMDGSERR AVVNSSLGWP GGVAVDAISE RVYWTDERLR AIGSAALDGD DIRILQMKET
TNPFSVVVLN DMLYWSDPKK RVVQAAHKVS GKNHQVLLKR PRQPFAVTII HPTLQVGIEG
PCKKMGCSHM CVLAPGPRAV CKCPSGLLLA EDGLTCSNLV NSAFLLLLSP STVTQIYLQS
QHTAAEVKGW PEHLALQIPS VNKAIIMDYS LNEHTLFVTD DATTSLRSFK LKDSLLTSQG
QLLELLDDTI TAMALDWITL NIYWSSDKQP RLXVTAATGT YTAILIKEGI RRVESIALHP
PSGKVCFTNM DLQVSGKTAT IECASMDGAE RRAVWKDAVQ PTSLVFSNNG DKIFWADTSL
GTIGSILIDG SGYTELKADD GLAAVALCDD LLLWMTVIDK TSLKAFSKSS QMGSNQCTEN
NGNCEHLCLA TPGGHTCKCS HDHILLNDTH CSPEQHCPAG SRPCLDQLSC QPVEKFCNGQ
ADCTDHSDEN CVGKKQRSGA EVFAPTQPHS SPPSSLPPLS EVTGQNTTLN VSTRLMNLDA
QQCSQRLCSN NGHCVEMKGV TTCVCSLGYS GDSCQDHLLK TMQGSIVYAA VGLGAAVVII
VAIVLVKRKK SANLRCLFVF SLKMTGHMGV SSLSFLSCGL FWACITSARG W
//
