ID A0A3Q0S5V6_AMPCI Unreviewed; 578 AA.
AC A0A3Q0S5V6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000017238.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000017238.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR AlphaFoldDB; A0A3Q0S5V6; -.
DR STRING; 61819.ENSACIP00000017238; -.
DR Ensembl; ENSACIT00000017708.1; ENSACIP00000017238.1; ENSACIG00000013436.1.
DR GeneTree; ENSGT00940000164585; -.
DR OMA; MWTDSEL; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd10492; MH1_SMAD_4; 1.
DR CDD; cd10498; MH2_SMAD_4; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF34; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 14..138
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 349..578
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 164..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 33..60
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 247..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 63130 MW; A42512C0E3E27411 CRC64;
MSVNPPSSND ACLSIVHSLM CHRQGGENEG FAKRAIESLV KKLKEKKDEL DSLITAITTN
GVHPSKCVTI QRTLDGRLQV AGRKGFPHVI YARLWRWPDL HKNELKHVKF CQYAFDLKYD
SVCVNPYHYE RVVSPGIVGL SLQNAGGLIK EEYIPDCIQM DLPPGMPLSD HQAAPDHYSP
LLPPSQLSSE PHGPSPVTRY PNLPVSPKVP ASGSMLPLQG SHGDGRLQTP SPQAQVVQPR
PPSPPQVASQ QQAAQHPSQH THSQQPPLPP SHLNRQNGYS SNKQSQTQPA FHTVWTGSST
ASYTPIGPQQ NGRGHQQPPL HLPNHHWSQH HSSTSFAPSV SNHPGPEFWC SVSYFEMDVQ
VGEMFKVLSS CPVVTVDGYV DPSGGDRFCL GQLSNVHRTD ASERARLHIG KGVQLECRGE
GDVWMRCMSD HAVFVQSYYL DREAGRAPGD AVHKIYPGAY IKVFDLRQCH RQMQQQAATA
QAAAAAQAAA VAGNIPGPGS VGGIAPAVSL SAAAGIGVDD LRRLCILRLS FVKGWGPDYP
RQSIKHTPCW VEVHLHRALQ LLDEVLHTMP LTDPGPAN
//
