ID A0A3Q0SC23_AMPCI Unreviewed; 778 AA.
AC A0A3Q0SC23;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Cadherin 11, type 2, OB-cadherin (osteoblast) {ECO:0000313|Ensembl:ENSACIP00000017950.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000017950.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000017950.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3Q0SC23; -.
DR STRING; 61819.ENSACIP00000017950; -.
DR Ensembl; ENSACIT00000018436.1; ENSACIP00000017950.1; ENSACIG00000013971.1.
DR GeneTree; ENSGT00940000153691; -.
DR OMA; ERYFVIN; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0048840; P:otolith development; IEA:Ensembl.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF85; CADHERIN-11; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 594..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..138
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 139..247
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 248..362
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 363..467
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 467..585
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 778 AA; 86241 MW; FCB68A2F461A1EAF CRC64;
INRQTMFDCH LSLHRHRQRV GKEGQVLHRS KRGWVWNQFF VIEEYTGPDP VLVGRLHSDV
DSGDGNIKYI LSGEGAGTIF VIDDKTGNIH ATKTLDREEQ AQYTLTAQAV ARDTNKPLEP
PSEFIVKVQD INDNPPEFPH GPYYARVPEM SNVGTSVLQV TATDADDPTY GNSARLVYSI
LQGQPYFSVE PQTGIIRTAL PNMDREARQE YDVVIQAKDM GGHMGGLSGT TEVKITLTDV
NDNPPKFPQS VYPMSVSEDK VPGEEVGRLK AKDPDLGDNG LVNYRLIDGD GMNMFELTTD
SETREAVIKL RKPVDFETKR SYTLKVEGSN PHIDPQFLAW GPYKDEATIK ISVEDADEPP
VFVAPSYTFE VEENAPPGTV VGRVHAKDTD VANNPVRYMI PRYTDVEQFF SINAEDGMIT
TAKPLDRETQ PWHNISVSAT EIGGHHQDTK VRVNINVKDV NDNPPEFATN NEVLMCETVA
PGKVIETVSA VDKDEMAHRQ HFTFNLAPEV AHNHNFSLKD NRDSTASIYV LRKGFSRLTQ
DVYFLPIEIN DNGIPAMSST NTLTIRVCSC DSKDTILSCN VEPYVLPAGL STGALIAILA
CIVILLAIVV LFVALRRQKK EPLIVFEEED IRENIITYDD EGGGEEDTEA FDIATLQNPD
GANGFLPRKD IKPELQYPIR PGIGRPAANS VDVDDFIKTR IAEADSDPTA PPYDSIQIYG
YEGRGSLAGS LSSLESVTTE SDLDYDYLQS WGPRFKKLAD LYGTKDCSIN DADDGEDS
//
