ID A0A3Q0SFH0_AMPCI Unreviewed; 1053 AA.
AC A0A3Q0SFH0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Zinc finger E-box binding homeobox 1b {ECO:0000313|Ensembl:ENSACIP00000019060.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000019060.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000019060.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSACIT00000019573.1; ENSACIP00000019060.1; ENSACIG00000014765.1.
DR GeneTree; ENSGT00950000183208; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF18; ZINC FINGER PROTEIN 1; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 135..163
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 165..192
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 205..232
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 823..850
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 851..878
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 879..907
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..972
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..994
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1031
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 115177 MW; 7FFEC0D9A37CE91D CRC64;
MADGPRCKRR KQANPKRTNV TNYNNVVEAG SDSDDEDKLH IVEEEGSLAD GADCESTLPD
DEHPREHCWD RVKEDCVTDG EDDVSTDALV EEMLQQGDTA VIYPEAPDDE PQRQGTPDTS
VHDENGTPDS FSQLLTCPYC ARGYKRYSSL KEHIKYRHEK TEESFSCPEC SYSFAYRAQL
ERHMTVHKSG RDQRHITQSG GNRKFKCTEC GKAFKYKHHL KEHLRIHSGE KPYECSNCKK
RFSHSGSYSS HISSKKCISV ISVNGRARLG NAKTQSQGSS PGLSTPPSVL RTQIREKLEH
SKPLQEQLPL NQIKTEPVDY EYKPTVITSP TLTAMNGGVF NGGAAAPLQG TVQAVVLPTV
GLVSPISINL ADLQNALKVA VDGNVIRQVL ENNAKGQVNS GLTTGTLHPP QQQLISAISL
PIVGQDGNAK IIINYNLDPN QGQLTAHNLK KEPDPVSPAQ TTTDTFKSQK LPEDLTVKGS
RTTKTCLLCD NCPGGLEALH ALKHCKKDGL KLNGAGLDRS DSAVAALLSE GGLCGQPKNL
LSLLKAYFAL NAKPTKDQLA KISDSVSLPV SVVEKWFDKM QEGQISLGAP TPPSEEEDTC
ESNSVVSLGP GKDKATIIPP VTQDSPTEAT PAEVNGTHSS PASPSPLNLT AEGPGPAKTP
QSTEGPLDLS LPKPARDETE RVAPKPCLYS SPSSGSTNED EPLNLTCTKK DASPLSAMGT
CPAALYASQP SAKPLDIVTT MQCLRALATN NKQTILIPQL AYTYTTTXNS PAGTETHETI
HLNGVKEDRQ DTGSEGVSTV EEQNDSDSGP PRKKMKKTDS GMYACDLCDK IFQKSSSLLR
HKYEHTGKRP HECGICSKAF KHKHHLIEHM RLHSGEKPYQ CDKCGKRFSH SGSYSQHMNH
RYSYCKKETQ SQAGGQESPE EDGEAQIDME VLSRAQRQHL APSQLDSDER GSSTREDEES
EEEEEEEGVV DMDDIQVVQI GDEGGEEEEE PEERNEEEMK RVVVGEGGEE EKTEIGXEEA
DSRQEDVIRS IQEETEMEEE EPGKKKSDSG ILK
//
