ID   A0A3Q0SFP7_AMPCI        Unreviewed;       705 AA.
AC   A0A3Q0SFP7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 {ECO:0008006|Google:ProtNLM};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000021822.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000021822.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSACIT00000022395.1; ENSACIP00000021822.1; ENSACIG00000016820.1.
DR   GeneTree; ENSGT00940000167169; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR45899:SF1; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          1..83
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          158..256
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          365..541
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          573..646
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
SQ   SEQUENCE   705 AA;  80064 MW;  37CF313E884BB04E CRC64;
     MTVSSCVPGQ HRSLGPSISK VRSLKLDCSI WSNELVELFL EVGNKNANSF WAANLPLEED
     LHSGAFAEQR ATFIRRKYRE RRYRRVLEGF HDLEQLNQAL CAAVVSSDVL QTMALVFSGA
     DVMCATGDPT YSTPYLLAQR AGQKLQMEFL HQNKLCGDSN LQEQLANQSG NMARRWCTLE
     GGFLSYYESE QSPSAIGRVD VTKVISLAVS HTETMTGAGA VFTVELYLQT ERVLIFGAET
     QETQHDWIQA LTKCFVPPKV EGLVRQESEL IGRLHYKEGH DLYYWRTGWF MLEGSTLHFS
     SGEEEGEEEV IQLKQLQELS KQGFLLMVEC GRTVYIHGFN KMDFTLWHSA IRLAAGTDGN
     ALGDQQLTKN GVPIVVDSCI AFVTQYGLCQ EGVYQRPGDP GRVSHLLEEF TRDARNVKLR
     KKEHHVEDVT DTLKSFLSQA EDALLTKELY PYWVSALDER DERQRVKKYS TFIESLPKIN
     RSTLQALLQH LYRIQQCSHL NHMPSEKLAS VFSSCLFQTQ GQTTQEISVV HDLISNYITL
     FSVSQKCSFF FFFFFFAVSI DKNKKLIGLS SVVSPSMRSA ELAETXLSMR SITVNAEDFW
     TTFEVIENGE LERPLHHSEK VLEQVLEWSS LDYPSSAFLV IKKFIGVKKV XHGKDQRQFL
     KGDHLKFSDG CSKLLSGHKF QDKYVVLHAE KLLLYRDIKV STLLA
//