ID   A0A3Q0SFW0_AMPCI        Unreviewed;       828 AA.
AC   A0A3Q0SFW0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Chloride channel, voltage-sensitive 2a {ECO:0000313|Ensembl:ENSACIP00000019210.1};
GN   Name=CLCN2 {ECO:0000313|Ensembl:ENSACIP00000019210.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000019210.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000019210.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3Q0SFW0; -.
DR   STRING; 61819.ENSACIP00000019210; -.
DR   Ensembl; ENSACIT00000019728.1; ENSACIP00000019210.1; ENSACIG00000014927.1.
DR   GeneTree; ENSGT00940000155439; -.
DR   OMA; EAQKWMH; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR   CDD; cd03683; ClC_1_like; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   PANTHER; PTHR45720:SF14; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        118..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        335..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        443..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        476..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        795..822
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          671..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   828 AA;  92486 MW;  103CAF9793FA77A5 CRC64;
     MPVEGHRFSL VFSAGVVFSV RITSPLETRA LCLWERFLAA GTALPMYGRY TQELGVFAKE
     EAARLRDGGV RDGGGMRRNA SVRSRADLLE YEKDPCAKCQ LCASRCQKFL ISRVGEDWIF
     LILLGLLMAL VSWVMDYAIA FCQEDQWMDR HSDEMCILKL YEYQSAFPLA LHLFFPSLSM
     KTILRGVVLK EYLTFKTFVA KVIGLTCALG SGMPLGKEGP FVHVASLCAA LLSKFMAAVF
     GGIYMNELRN TEMLSAACAV GVGCCFAAPI GGVLFSIEVT STFFAVRNYW RGFFAATFSA
     FIFRVLAVWN QEEETITALF KTRFRLDFPF DLQELPAFAI LGIACGFGGA LFVYLNRLIV
     ECMRKQKTIN KFLLRKRLVY PALVTLLIST LTFPPGFGQF MAGQLTQHES LVALFDNRTW
     CRQGVAEEFD YTSHHHAWKH PQVNVFITLI LFTVMKFWMS AVATTMPVPC GAFMPVFLIG
     AAFGRLVGEI MAAMFPDGIH AAGSVYPIVP GGYAVVGAAA LSGAVTHTVS TAVIVFELTG
     QISHILPVMI AVILANAVAQ ALQPSLYDSI IRIKKLPYLP ELGMGHHEKY NIRVEDIMVR
     DVRYITLNSS YRELQEMLMT GQLKTLALVE SRDSMILLGS IERLQLQSLL SLQLSRQRRL
     EYLRQLAQDN GTHDHLPSLT SDSTPSSPCT HTHLNSSSNS SARQAVRFLV STQQIAEWEE
     QQLDEPVDFK NCKIDPAPFQ LVEQTSLHKT HTIFSLLGLD HAYVTSMGRL VGVVSLKEVC
     MCARSLKNSS LMNDVLFICS LVSPLLFLDL FSWLCFLSFF FFSCWLRL
//