ID A0A3Q0SFW0_AMPCI Unreviewed; 828 AA.
AC A0A3Q0SFW0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Chloride channel, voltage-sensitive 2a {ECO:0000313|Ensembl:ENSACIP00000019210.1};
GN Name=CLCN2 {ECO:0000313|Ensembl:ENSACIP00000019210.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000019210.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000019210.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q0SFW0; -.
DR STRING; 61819.ENSACIP00000019210; -.
DR Ensembl; ENSACIT00000019728.1; ENSACIP00000019210.1; ENSACIG00000014927.1.
DR GeneTree; ENSGT00940000155439; -.
DR OMA; EAQKWMH; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF14; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 671..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 92486 MW; 103CAF9793FA77A5 CRC64;
MPVEGHRFSL VFSAGVVFSV RITSPLETRA LCLWERFLAA GTALPMYGRY TQELGVFAKE
EAARLRDGGV RDGGGMRRNA SVRSRADLLE YEKDPCAKCQ LCASRCQKFL ISRVGEDWIF
LILLGLLMAL VSWVMDYAIA FCQEDQWMDR HSDEMCILKL YEYQSAFPLA LHLFFPSLSM
KTILRGVVLK EYLTFKTFVA KVIGLTCALG SGMPLGKEGP FVHVASLCAA LLSKFMAAVF
GGIYMNELRN TEMLSAACAV GVGCCFAAPI GGVLFSIEVT STFFAVRNYW RGFFAATFSA
FIFRVLAVWN QEEETITALF KTRFRLDFPF DLQELPAFAI LGIACGFGGA LFVYLNRLIV
ECMRKQKTIN KFLLRKRLVY PALVTLLIST LTFPPGFGQF MAGQLTQHES LVALFDNRTW
CRQGVAEEFD YTSHHHAWKH PQVNVFITLI LFTVMKFWMS AVATTMPVPC GAFMPVFLIG
AAFGRLVGEI MAAMFPDGIH AAGSVYPIVP GGYAVVGAAA LSGAVTHTVS TAVIVFELTG
QISHILPVMI AVILANAVAQ ALQPSLYDSI IRIKKLPYLP ELGMGHHEKY NIRVEDIMVR
DVRYITLNSS YRELQEMLMT GQLKTLALVE SRDSMILLGS IERLQLQSLL SLQLSRQRRL
EYLRQLAQDN GTHDHLPSLT SDSTPSSPCT HTHLNSSSNS SARQAVRFLV STQQIAEWEE
QQLDEPVDFK NCKIDPAPFQ LVEQTSLHKT HTIFSLLGLD HAYVTSMGRL VGVVSLKEVC
MCARSLKNSS LMNDVLFICS LVSPLLFLDL FSWLCFLSFF FFSCWLRL
//