ID A0A3Q0SG99_AMPCI Unreviewed; 692 AA.
AC A0A3Q0SG99;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000022077.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000022077.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00000251,
CC ECO:0000256|RuleBase:RU610713};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC {ECO:0000256|ARBA:ARBA00008871, ECO:0000256|RuleBase:RU610713}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSACIT00000022665.1; ENSACIP00000022077.1; ENSACIG00000016859.1.
DR GeneTree; ENSGT01020000230364; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR018155; Hyaluronidase.
DR PANTHER; PTHR11769; HYALURONIDASE; 1.
DR PANTHER; PTHR11769:SF20; HYALURONIDASE PH-20; 1.
DR Pfam; PF01630; Glyco_hydro_56; 1.
DR PRINTS; PR00846; GLHYDRLASE56.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU610713};
KW Hydrolase {ECO:0000256|RuleBase:RU610713};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 87..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 76731 MW; C59649A3C2491BB1 CRC64;
MVSVAQKSRG CVPLLLFFTR SIFPFSFFAA LAALTAPIAT TLPVADVNKS ILILPATIST
LSVQKSPTVS PSQTYFSSPA STSRSLSKLP LKADSNPESS ASETSVPLCN PASHRDVPTS
PSTSKKIHLP GKKVSASLFS GHCHHTSFYP FQPLKQISWL PSDPCKHLNL SYKTIKPLSH
KNLQSPQTKS CLYPVSAQKV HLQPANPPKP QSPFSPAPLF LLSNSTLVPS LPQSALKNLL
SPLSVSSLSA ALTLKTTPPA LSKKSQLPPY KTTSSPPEVT TSRLAPAHLP HATGPLFEHQ
PFTVTWNIPD LVCNRYNISL DTSPFKGVAT PVPGQFLSLF YTDRLGLYPH IDLKSRKKFH
GGIPQRANLK AIDPFYLGLA VIDWEEWRPL WDRNWGTKRI YQTLSVAHVM QANLSLTVEQ
ATVKAKQQFQ EAARNLMSEM LALGRAMRPN YLWGFYLFPN CYNYGWQDLH YTGQCSMEVR
RQNDELLWLW ESSTALYPSV YLQVAALMVR NRVQEALRVS ALPGWRAAAP VFVYMRPVFV
DDNKRFLSQR DLISTVGESV AVGASGTVLW GASADYDDQM SCEALSSYLT STLNPYITNV
TTAAQLCSDF LCRGNGRCVR KNYKSNHYLH LNPESFRVVR IQKRYFVLGS PSLADLKSLS
RRFNCQCYKG LINTXSHWCI RSGCSHCGVC GV
//
