ID   A0A3Q0SI27_AMPCI        Unreviewed;       545 AA.
AC   A0A3Q0SI27;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000021348.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000021348.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 61819.ENSACIP00000021348; -.
DR   Ensembl; ENSACIT00000021901.1; ENSACIP00000021348.1; ENSACIG00000016577.1.
DR   GeneTree; ENSGT00940000168817; -.
DR   OMA; PFHENTE; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd01671; CARD; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          29..89
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   DOMAIN          160..275
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   545 AA;  62515 MW;  23760200B2045ECD CRC64;
     NHEVEGTAQG AQRLNCGTDL TKVTKERHLV RTLKGLTVIV ENLYQKGVFS EEEVSKIKTE
     VDDFEKTRRI VDSVINKGEA ACYEFLRIID ITRKRSTERP PPFHENTELT SSSRDTFDLN
     YWISCFSFEE DINMDVTYLQ GIFKHTEVTS PDLLLKTYEK NILLVGKPGV GKTAVVHQML
     KLWSEKDKDL DYMFYFDMRE TPTITEVHKL EDLLFGVFSE PDEGKDEVLE DIKKNADSVT
     FIFDGVTDVP STSVVFKLIQ KTLLPEAKII ITCRPEDESA DFLLDWDCLR VEVKGFSEQG
     IREYLSKNLS EEHLNQVLCN LELFTLCHVP MYXLMVAACF SFEGSDVSPH PCTVTEIYLN
     ILHICIQRNV CKNLKNQTSQ CNSILSLAEA ASCAIEEKNV NLSSLSQLDS CVHLSILNTL
     LIQVGPTVKK RSCAFLHYTV QEFFAALWVL KDPERTRGVL QQCLTEDMKH MKHLVPFLCG
     LLNEKNKDLL ESLIPSQQLR DTSGWFFKDL VNTFPLMCFV VKVYWKIYTF LKKICPFYSK
     VFAFV
//