ID A0A3Q0SIK5_AMPCI Unreviewed; 867 AA.
AC A0A3Q0SIK5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK3 {ECO:0000313|Ensembl:ENSACIP00000022851.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000022851.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000022851.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR AlphaFoldDB; A0A3Q0SIK5; -.
DR STRING; 61819.ENSACIP00000022851; -.
DR Ensembl; ENSACIT00000023458.1; ENSACIP00000022851.1; ENSACIG00000017772.1.
DR GeneTree; ENSGT00940000159465; -.
DR OMA; FMQCEIN; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF174; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 563..582
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 639..661
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 820..844
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 433..801
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 443..507
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 867 AA; 98623 MW; 350A8833AEF0FCFA CRC64;
MRNTWLSPRS AIRDYWTSLI ACLFWIQYSY GMPHVIRIGG IFEQTDGPVS LVSAEELAFK
FAVNNINRNR TLLPNTTLTY DIQRINIYDS FEASRKACDQ LSLGVVAIFG PSHSSSSNAV
QSICNALEVP HIQVRWKHHP MDNRDTFYAN LYPDYSSLSY AILDLVQFLK WKTATVVYDD
STGLIRLQEL IMAPSRYNIR LKIRQLPLDT QDTRPLLKEM KRSREFRIIF DCSHHMAAQI
LKQAQTMGMM TEYYHYIFTT LDLMAIDLEP YRFCGVNMTG FRILNVDNPQ VASIVEKWSM
ERQIPPKPDS GLLEGIMTTD AALTYDAVHI VSVSYQHAPQ MTVNSLQCHR HKPWRFGGRF
MSFIKESHWD GLTGRLSFNK TTGLRTDFDL DIISLKEDGL EKVGKWSASG GLNITEVPKR
KGMNITDSLA NRSLVITTIL EEPYVMLKKS DKALVGNDRF EGFCIDLLKE LANILGFTYE
IRLVPDGKYG SQDDKGQWNG MIRELIEHRA DLAVAPLTIT YVREKFIDFS KPFMSMGISI
LYRKPNATNN GFFSFLNPMT PDIWVYILLA YLGVSCVLFV IARFSPYEWY DAHPCNPGSD
VVENNFTLLN SFWFGVGSLM QQGSELMPKA LSTRIIGGIW WFFTLIIISS YTANLAAFLT
VERMDSPVDS ADDIAKQTKI EYGVVKDGAT MSFFKKSRVS TFEKMWAFMS SRPRTSLVKS
IEDGIQRVLK SDYALITEST TIDYITRRNC NLTQVGGLID SKGYGIGTPL GSPYRDKISI
AILSILEDGR LHMLKEKWWS GSSCLDERHR ETGPMGIQNL GGIFIVLASG LVLSVFVAIA
EFIYKLRKTA EREQVYVPIN QLKNIFF
//
