ID A0A3Q0SKG5_AMPCI Unreviewed; 371 AA.
AC A0A3Q0SKG5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000023462.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000023462.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR AlphaFoldDB; A0A3Q0SKG5; -.
DR STRING; 61819.ENSACIP00000023462; -.
DR Ensembl; ENSACIT00000024077.1; ENSACIP00000023462.1; ENSACIG00000018224.1.
DR GeneTree; ENSGT00940000157617; -.
DR OMA; EHARMLM; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
DR GO; GO:0060030; P:dorsal convergence; IEA:Ensembl.
DR GO; GO:0010172; P:embryonic body morphogenesis; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
DR GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
DR GO; GO:0090156; P:intracellular sphingolipid homeostasis; IEA:Ensembl.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0021555; P:midbrain-hindbrain boundary morphogenesis; IEA:Ensembl.
DR GO; GO:0042692; P:muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0048884; P:neuromast development; IEA:Ensembl.
DR GO; GO:0048840; P:otolith development; IEA:Ensembl.
DR GO; GO:1904105; P:positive regulation of convergent extension involved in gastrulation; IEA:Ensembl.
DR GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
DR GO; GO:0008591; P:regulation of Wnt signaling pathway, calcium modulating pathway; IEA:Ensembl.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0061053; P:somite development; IEA:Ensembl.
DR GO; GO:0002574; P:thrombocyte differentiation; IEA:Ensembl.
DR GO; GO:0009826; P:unidimensional cell growth; IEA:Ensembl.
DR GO; GO:0007223; P:Wnt signaling pathway, calcium modulating pathway; IEA:Ensembl.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF87; PROTEIN WNT-5B; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 371 AA; 42112 MW; 63DEAE7AEAFBCFE1 CRC64;
MDNRPVRTKR TGPVRHLLLA AAFLACSCQL LMVDANSWWS LGLTPMQRPE MYIIGAQPLC
SQLLGLSQGQ RKLCQLYQDH MTYIGDGAKT GIKECQYQFR QRRWNCSTVD NTSVFGRVMQ
IGSRETAFTY AISAAGVVNA ISRACREGEL STCGCSRTAR PRDLPRDWLW GGCGDNVHYG
YRFAREFVDA REREKNYPRG STEHARMLMN LHNNEAGRQA VYNLANVACK CHGVSGSCSL
KTCWLQLADF RRVGEFLKEK YDSAAAMRVG RKGKLELLDK RFNPPTAQDM VYIDPSPDYC
LRNETTGSLG TQGRLCNKTS EGMDGCELMC CGRGYDQFKT YKHERCHCKF HWCCYVKCKR
CTTLVDQFVC K
//
