ID A0A3Q0SLE5_AMPCI Unreviewed; 640 AA.
AC A0A3Q0SLE5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rabphilin 3A homolog (mouse), b {ECO:0000313|Ensembl:ENSACIP00000022558.1};
GN Name=RPH3A {ECO:0000313|Ensembl:ENSACIP00000022558.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000022558.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000022558.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q0SLE5; -.
DR STRING; 61819.ENSACIP00000022558; -.
DR Ensembl; ENSACIT00000023160.1; ENSACIP00000022558.1; ENSACIG00000017546.1.
DR GeneTree; ENSGT00940000157468; -.
DR OMA; ERGPNCC; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04035; C2A_Rabphilin_Doc2; 1.
DR CDD; cd08384; C2B_Rabphilin_Doc2; 1.
DR CDD; cd15762; FYVE_RP3A; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR028698; FYVE_RPH3A.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR InterPro; IPR047022; Rabphilin_Doc2_C2A.
DR InterPro; IPR001565; Synaptotagmin.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45729; RABPHILIN, ISOFORM A; 1.
DR PANTHER; PTHR45729:SF3; RABPHILIN-3A; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 26..142
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 74..130
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 345..467
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 496..629
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 70928 MW; B4C77E81CA7D7B78 CRC64;
MTDTVMSSSS DRWVSNDRQR SMHPGPGPGP DLTDEEKEII NSVIARAEKM EAMEQERIGR
LINRLDDMKK TVCGDGVSRC LLCGEQLGSP GVSSVVCEDC KKNMCTKCGT QCGSRPRAVW
LCKICREQRE VWKRSGAWFF KGFPKHFLPS PMPLSKSKET GAQEAAEPQR PKTSEARETV
TQQQAPGPEP QGRPGYPPVA PKPVMRMATG GAGPEEAGQG SPVVMKKMVP VQSSRPQPAA
STNMTQQGEK QLRHSPLLMS LQKETSPSGV ISCSLKQLNV VVGSVIGDGG AYSSGAVPPE
QRAPPAVRED RRQPTAYSAP PARQQPPPAE EEEEANDYDS DEATTLGSLE FSLLYEQESS
SLHCGILKAK GLKPMDSNGL ADPYVKLHLL PGASKSNKLR TKTLRNTRNP VWNETLTYHG
LTDEDMQRKT LRVSVCDEDK FGHNEFIGET RVALKKLKLN QKKNFNVCLE RVVPTKRTAT
VGAARGIALY EDEVEERGRI LISLLYSSQQ NRLIVGAVRC VHLAAMDANG YSDPYVKICL
KPDMGKKGKC KTQIKKRTLN PEFNEEFGFD IKHSELAKKT LDISVWDYDI GKSNDYIGGC
QLGITAKGER LKHWYECLKN KDKKIERWHT LYNENHVASD
//
