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Database: UniProt
Entry: A0A3Q0SM31_AMPCI
LinkDB: A0A3Q0SM31_AMPCI
Original site: A0A3Q0SM31_AMPCI 
ID   A0A3Q0SM31_AMPCI        Unreviewed;      3864 AA.
AC   A0A3Q0SM31;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=PRKDC {ECO:0000313|Ensembl:ENSACIP00000025924.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000025924.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000025924.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC       {ECO:0000256|ARBA:ARBA00011031}.
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DR   Ensembl; ENSACIT00000026605.1; ENSACIP00000025924.1; ENSACIG00000015308.1.
DR   GeneTree; ENSGT00940000155633; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05172; PIKKc_DNA-PK; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR037706; DNA-PK_dom.
DR   InterPro; IPR046804; DNA-PKcs_N.
DR   InterPro; IPR046803; DNAPKcs_CC1-2.
DR   InterPro; IPR012582; DNAPKcs_CC3.
DR   InterPro; IPR045581; DNAPKcs_CC5.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR   Pfam; PF20500; DNA-PKcs_N; 2.
DR   Pfam; PF20502; DNAPKcs_CC1-2; 2.
DR   Pfam; PF08163; DNAPKcs_CC3; 1.
DR   Pfam; PF19704; DNAPKcs_CC5; 1.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM01344; NUC194; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          2674..3325
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
FT   DOMAIN          3512..3789
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   DOMAIN          3832..3864
FT                   /note="FATC"
FT                   /evidence="ECO:0000259|PROSITE:PS51190"
FT   REGION          1905..1930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1905..1926
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3864 AA;  439619 MW;  8C8A80852B05972B CRC64;
     MSSLSSAAGG IQGLLLKLHE LLADEDIRAA ALKCHDIIGD LGQECMISDS IFASSSHQAL
     QTSLLFSKDY GLLAFLRKSL ALDELRDTRV EILGFLENVA LNGLCNITRL KTRCTFVLQT
     TKASSVAADF RISEIFNKYY SELCQKSKLP DSVLGKIYEL LGVLAEVHPS EMVNNSDKLY
     RAYLGELKDQ MTSKTKEPKL LVVAGCLRGV TALMVNFSKT MEEDPATSKE IFQYAFKSIT
     GLRLFTRHAS QFSSCLMDHY KALFEIMSKL CGHINGEMKK TSYYALEAFL KQVAMLVADN
     IEEHKTKLKF FMQKFCGIIK TMDSTHKELS IAIRGYGFFA APCKKVCPQD VDLMYTELIQ
     RCKQMYLTES DGEDDSFYQL PSFLDSIASV IIHLDKIPEV YTPLLERLLV VQIDSFPQYS
     ERMQITSSRS ILKVLVAIAS KGPVLWSFIS SVVHQGLIRV CSKPLTGSSE PSLVRTGKWK
     VPASHDYLSL YKALLDCDQL KDSGFLDGAF ESQNAALGSL SRLLYDELVK SILRIVEKLD
     LSVQKVTTGE EAPDDAAHML PSSDPTAHLL PNKVKDFTAF INLVDFCSEL LLNKHMEYFQ
     SWMYPLSHEL ILHSIRNPLV SGFYKLLSVT MKIAKRLKFT EKFTGDIIYL CVLFIMKQYK
     DELLASCLTF VLSLHHNIVA LDIKAYCPAL ENALKLGLSH VPLANAALDA LEDWSSHIPL
     ETMQPCYTSI LPLLDGYLKT SSTDNESNWE VMSSSSKSER GYSRVMRSVA FELTGKLNRN
     LVTVVSSEEM MKKFVSWDAE KRLSFAVPFR DMKPVVYLDP FLPHISELAL STSDRQTKVA
     ACELLHSLVV YMIGKSAQMV EGENSLPPMY KLHKRLFPVL LRLACDVDQV TRQLFEPLVM
     QLIHWFTNNK KFESQDTVAV LEAILDGVVD PMDSTLRDFC GRCIEEFVKW SIKQTTPKQQ
     EKSPTNMKSL FKRIYSLALH PNGFKRLGAA LAFNSIYRQF REENSLVEQF VFEVLVIFVE
     SLALAHSDER SMGNCSFTTA LGFPPDEKLC LSDVVLWLLE QCGRPQTECR HRCMALLYEF
     IPLLPGKKSP PQWLDGMLKD HGTDFLISRF EGGGLSSQPT LRDLTGPFSV RATLQWMDLL
     LAVLDCYNTF ISLHIIKPQY ILSSKDKSSF LKAVHFFLTE LATHELVAAE SCFPLGEKTS
     HFSPREVEQY SYSKCTIIVR LLEFTTMILL KGDKELWKFL EQDFFCSVFF ELTAMVVCEP
     SGVGFNMADV EVMKNLPEVC VPLLKALLAS PYHGHLESSL RTKISRKRCV CAYVLFHLEF
     AVRGKRYGAS ILIGLSDTSV NMNTSLLMTV YKGIAPGEDR KALPSLDVNT RRVADGLLQL
     AFSLMFYCFL LEQLVDLLLN TIMLSVPVSG SHSHNFLSFS HGEYFYSLFQ LTINTELLRS
     LNTTVPRLMK ASSQNPSMVS VLLNGMLDHS FRERSVRKTQ GKQLVEEVLR RWMSLQSWWE
     GDSSTPESKT AILLLLSKLL QIDSSVCSNI SHEAFRPVFS TFTMLLVDMN LPLNLKSQAL
     LVLPFFTTLP EEPLAELQVA LDTLVASHFP MQSDEFAKGS LHRNNYMDCI RKLLDALELS
     QSPLLLKLLA GILCRDTKHI MEEQFQTCFQ RIAKRLVKVL NLWDLTQSLR FLSMLQAMME
     RVLLPLASHC STKALNDFFV ANVFDIISFL LSRFTKSNET TFESQLLKKN GCYKLMELLY
     SRLPKEEVYS KESRINQAYC RTDKPEGNEM SKTLIKSCFE AFTENMAGET QLLELRRHYH
     CAAYNCAVAV ISCSFSEPKF YHGFLFSEKP EKDLIDCFFS PVFQNHFPIE IEVPLARKKK
     YIMIRKDVNE ENGEAPVYLS SQSYMADSSL SEEMSQFDFS TGVQSFSFSS QNPEGQKQTP
     ETSPSQDAMV DLEMDELNQH ECMATMTALI GHMQRSNITP KIEQGTVPSE LPPWMKFLHG
     KLANPATPLN IRLFISKLII NTEEVFRPYA KYWLGPLLQL VVSGNSGGEG IHFMVVDVVV
     TVLSWTSLAS PKGNPRDEVL ANRLLEFLMK HSFHSKRAVF RHNLEIIRTL VECWKDCLHV
     PYSLIYERFS GTDANSKDNS VGLQLLGIIL ANNLPAYDAS CGIEYESYIQ SLTNNMSFVR
     YKEVYSAAAE IIGLILKSMS EIGEITNLKK KEQDDKFIIC LNKVSNVFIL HGILKTNCLE
     CVLSRADVIP DIFLQLKTTG FIQMMSHRDE ARQRACLDII HKILARLSPV ELQELLGSVT
     AFVSHPSPVC RERMYDILMW IQDNYGXVFL ASYSISLEIF NAAKETLLQG LSEENQGLQL
     YVCNFWSQEK RLPTATLERM LMVLHSLYSC KIERSFLSLA TNLLLEMTSQ SPDFKRNMFE
     YPLSECTFQD YVIDSNWRFR STVMTPMFVE TQSSQGPESV AASQSGTMKG KLRATQTSLE
     FSQTQTEGRR TAYNWLTGSS VDTLAEYTLG SESLSSLLVK KRLKFHSVKS FKCKLYSLST
     AANEQRANIL RLRRRFLKDQ EKVSLSFAQK EIQQQRQKKV SSLRKEAQVT LYRNYRVGDF
     PDIQIPYSSL IAPLQALAQR DPILAKQLFS SLFTGILQEM DKQKRPEESS RIKEELRCNM
     NSFLSKSTLC FPPFISCVQV RSCFNSLTSL NPADISSTCL MSLQQPSGIL LLEEGLLHAD
     GPTERPAKRS RGRKEIPPDT NKWINLARLY RSLEDYDVVR GIFGGKVGTK SITCAALQAE
     ANTDFAEAVK LYNEALNTEN WSDGEPTDAE KDFWDRAAME AYSHLTEWKS LQYCSTVNID
     ENNPPNLEMM WSEPFYQEMY LQHMIRSMLK QLQLGERDQT LLSFIDNAMK LEERKKLLES
     HYSQELSLLY ILQEDYDRAK YYTNYALQLF MESYSSVDTL LTNSRLTILQ SVQALTEIQD
     FLLFIKGEGV NIFSTAYLVK LWTERYPDAK VDPVNVWDDI ITSRCFFLDK IREKLRGHAP
     SDSMEVDGSD DPAGDIETLV NDCKFNMKLR MADGAQKQNN FSVAGKLLKE LHREAKTNRR
     QLLRWVHSFS RYKHKQSQAQ GPVEQINTVV KTIPLLADCQ SATAKVFRYQ KILQGTSFDI
     LATAVGRSPS VLATVDADKA EKVVKLSGAA CVWLENEKVE VGLQLQALKL LCEATRKADE
     EVQSYSQEFV ETSSIIKTYM ALANFCDKRL REEEQRDTES QFPDLLVLPV HVVENMLKAL
     KMNSEEARLK FPRLLQIIEL YPSETLDLMT KEMMSVPCWM LISWISQMVA LLDKPEAVAV
     QHCIGQIAEC YPQALVYALM ISSESYQFED SATGHQQQEF VNRLRSLLDK GGAVKNFVEA
     LQQLTNPDMI FRDWWDGVKI ELEKXTFNKK QMGXMYEEMR SLLGDRNTNG HGMFRRKFIQ
     KFSKEVEKLL GPNGSKLFEK RKDKPFLQQV DNLLLSMREF RESQKEPGNL KEYSPWLNGF
     KADPFRNELE IPGQYDGRSK PLPEYHAKIT GFDERVKVMS SIRRPKRLII RGDDERDHPF
     LVKGGEDLRQ DQRIEQLFAV MNILLSRDTS CLHRGLQLRT YQVIPINTRI GLIEWMENTC
     TLKEFVHNTM TGEEQQSAKR RAFLKMCNSP EAFLSLRSHF VSSHALLCVS HWILGIGDRH
     LSNFMINMET GGMIGIDFGH AFGSATQFLA VPELMPFRLT QQFVNLMQPL KESGLIQSIM
     VHSLRAYRAA PDLLLNTMDV FVKEPSLDWK NFEVKQLKKG GTWRETVNTR EINWYPLQKV
     NFAKRKLEGA NPAAITSEEL KLGFEKDAAF PGMKSVALGT EQHNIRAKLP AEGLSVEKQV
     DCLLDQAMDP NVLGRVWVGW EPWI
//
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