ID A0A3Q0SM31_AMPCI Unreviewed; 3864 AA.
AC A0A3Q0SM31;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PRKDC {ECO:0000313|Ensembl:ENSACIP00000025924.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000025924.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000025924.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR Ensembl; ENSACIT00000026605.1; ENSACIP00000025924.1; ENSACIG00000015308.1.
DR GeneTree; ENSGT00940000155633; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 2.
DR Pfam; PF20502; DNAPKcs_CC1-2; 2.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2674..3325
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3512..3789
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3832..3864
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1905..1930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1905..1926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3864 AA; 439619 MW; 8C8A80852B05972B CRC64;
MSSLSSAAGG IQGLLLKLHE LLADEDIRAA ALKCHDIIGD LGQECMISDS IFASSSHQAL
QTSLLFSKDY GLLAFLRKSL ALDELRDTRV EILGFLENVA LNGLCNITRL KTRCTFVLQT
TKASSVAADF RISEIFNKYY SELCQKSKLP DSVLGKIYEL LGVLAEVHPS EMVNNSDKLY
RAYLGELKDQ MTSKTKEPKL LVVAGCLRGV TALMVNFSKT MEEDPATSKE IFQYAFKSIT
GLRLFTRHAS QFSSCLMDHY KALFEIMSKL CGHINGEMKK TSYYALEAFL KQVAMLVADN
IEEHKTKLKF FMQKFCGIIK TMDSTHKELS IAIRGYGFFA APCKKVCPQD VDLMYTELIQ
RCKQMYLTES DGEDDSFYQL PSFLDSIASV IIHLDKIPEV YTPLLERLLV VQIDSFPQYS
ERMQITSSRS ILKVLVAIAS KGPVLWSFIS SVVHQGLIRV CSKPLTGSSE PSLVRTGKWK
VPASHDYLSL YKALLDCDQL KDSGFLDGAF ESQNAALGSL SRLLYDELVK SILRIVEKLD
LSVQKVTTGE EAPDDAAHML PSSDPTAHLL PNKVKDFTAF INLVDFCSEL LLNKHMEYFQ
SWMYPLSHEL ILHSIRNPLV SGFYKLLSVT MKIAKRLKFT EKFTGDIIYL CVLFIMKQYK
DELLASCLTF VLSLHHNIVA LDIKAYCPAL ENALKLGLSH VPLANAALDA LEDWSSHIPL
ETMQPCYTSI LPLLDGYLKT SSTDNESNWE VMSSSSKSER GYSRVMRSVA FELTGKLNRN
LVTVVSSEEM MKKFVSWDAE KRLSFAVPFR DMKPVVYLDP FLPHISELAL STSDRQTKVA
ACELLHSLVV YMIGKSAQMV EGENSLPPMY KLHKRLFPVL LRLACDVDQV TRQLFEPLVM
QLIHWFTNNK KFESQDTVAV LEAILDGVVD PMDSTLRDFC GRCIEEFVKW SIKQTTPKQQ
EKSPTNMKSL FKRIYSLALH PNGFKRLGAA LAFNSIYRQF REENSLVEQF VFEVLVIFVE
SLALAHSDER SMGNCSFTTA LGFPPDEKLC LSDVVLWLLE QCGRPQTECR HRCMALLYEF
IPLLPGKKSP PQWLDGMLKD HGTDFLISRF EGGGLSSQPT LRDLTGPFSV RATLQWMDLL
LAVLDCYNTF ISLHIIKPQY ILSSKDKSSF LKAVHFFLTE LATHELVAAE SCFPLGEKTS
HFSPREVEQY SYSKCTIIVR LLEFTTMILL KGDKELWKFL EQDFFCSVFF ELTAMVVCEP
SGVGFNMADV EVMKNLPEVC VPLLKALLAS PYHGHLESSL RTKISRKRCV CAYVLFHLEF
AVRGKRYGAS ILIGLSDTSV NMNTSLLMTV YKGIAPGEDR KALPSLDVNT RRVADGLLQL
AFSLMFYCFL LEQLVDLLLN TIMLSVPVSG SHSHNFLSFS HGEYFYSLFQ LTINTELLRS
LNTTVPRLMK ASSQNPSMVS VLLNGMLDHS FRERSVRKTQ GKQLVEEVLR RWMSLQSWWE
GDSSTPESKT AILLLLSKLL QIDSSVCSNI SHEAFRPVFS TFTMLLVDMN LPLNLKSQAL
LVLPFFTTLP EEPLAELQVA LDTLVASHFP MQSDEFAKGS LHRNNYMDCI RKLLDALELS
QSPLLLKLLA GILCRDTKHI MEEQFQTCFQ RIAKRLVKVL NLWDLTQSLR FLSMLQAMME
RVLLPLASHC STKALNDFFV ANVFDIISFL LSRFTKSNET TFESQLLKKN GCYKLMELLY
SRLPKEEVYS KESRINQAYC RTDKPEGNEM SKTLIKSCFE AFTENMAGET QLLELRRHYH
CAAYNCAVAV ISCSFSEPKF YHGFLFSEKP EKDLIDCFFS PVFQNHFPIE IEVPLARKKK
YIMIRKDVNE ENGEAPVYLS SQSYMADSSL SEEMSQFDFS TGVQSFSFSS QNPEGQKQTP
ETSPSQDAMV DLEMDELNQH ECMATMTALI GHMQRSNITP KIEQGTVPSE LPPWMKFLHG
KLANPATPLN IRLFISKLII NTEEVFRPYA KYWLGPLLQL VVSGNSGGEG IHFMVVDVVV
TVLSWTSLAS PKGNPRDEVL ANRLLEFLMK HSFHSKRAVF RHNLEIIRTL VECWKDCLHV
PYSLIYERFS GTDANSKDNS VGLQLLGIIL ANNLPAYDAS CGIEYESYIQ SLTNNMSFVR
YKEVYSAAAE IIGLILKSMS EIGEITNLKK KEQDDKFIIC LNKVSNVFIL HGILKTNCLE
CVLSRADVIP DIFLQLKTTG FIQMMSHRDE ARQRACLDII HKILARLSPV ELQELLGSVT
AFVSHPSPVC RERMYDILMW IQDNYGXVFL ASYSISLEIF NAAKETLLQG LSEENQGLQL
YVCNFWSQEK RLPTATLERM LMVLHSLYSC KIERSFLSLA TNLLLEMTSQ SPDFKRNMFE
YPLSECTFQD YVIDSNWRFR STVMTPMFVE TQSSQGPESV AASQSGTMKG KLRATQTSLE
FSQTQTEGRR TAYNWLTGSS VDTLAEYTLG SESLSSLLVK KRLKFHSVKS FKCKLYSLST
AANEQRANIL RLRRRFLKDQ EKVSLSFAQK EIQQQRQKKV SSLRKEAQVT LYRNYRVGDF
PDIQIPYSSL IAPLQALAQR DPILAKQLFS SLFTGILQEM DKQKRPEESS RIKEELRCNM
NSFLSKSTLC FPPFISCVQV RSCFNSLTSL NPADISSTCL MSLQQPSGIL LLEEGLLHAD
GPTERPAKRS RGRKEIPPDT NKWINLARLY RSLEDYDVVR GIFGGKVGTK SITCAALQAE
ANTDFAEAVK LYNEALNTEN WSDGEPTDAE KDFWDRAAME AYSHLTEWKS LQYCSTVNID
ENNPPNLEMM WSEPFYQEMY LQHMIRSMLK QLQLGERDQT LLSFIDNAMK LEERKKLLES
HYSQELSLLY ILQEDYDRAK YYTNYALQLF MESYSSVDTL LTNSRLTILQ SVQALTEIQD
FLLFIKGEGV NIFSTAYLVK LWTERYPDAK VDPVNVWDDI ITSRCFFLDK IREKLRGHAP
SDSMEVDGSD DPAGDIETLV NDCKFNMKLR MADGAQKQNN FSVAGKLLKE LHREAKTNRR
QLLRWVHSFS RYKHKQSQAQ GPVEQINTVV KTIPLLADCQ SATAKVFRYQ KILQGTSFDI
LATAVGRSPS VLATVDADKA EKVVKLSGAA CVWLENEKVE VGLQLQALKL LCEATRKADE
EVQSYSQEFV ETSSIIKTYM ALANFCDKRL REEEQRDTES QFPDLLVLPV HVVENMLKAL
KMNSEEARLK FPRLLQIIEL YPSETLDLMT KEMMSVPCWM LISWISQMVA LLDKPEAVAV
QHCIGQIAEC YPQALVYALM ISSESYQFED SATGHQQQEF VNRLRSLLDK GGAVKNFVEA
LQQLTNPDMI FRDWWDGVKI ELEKXTFNKK QMGXMYEEMR SLLGDRNTNG HGMFRRKFIQ
KFSKEVEKLL GPNGSKLFEK RKDKPFLQQV DNLLLSMREF RESQKEPGNL KEYSPWLNGF
KADPFRNELE IPGQYDGRSK PLPEYHAKIT GFDERVKVMS SIRRPKRLII RGDDERDHPF
LVKGGEDLRQ DQRIEQLFAV MNILLSRDTS CLHRGLQLRT YQVIPINTRI GLIEWMENTC
TLKEFVHNTM TGEEQQSAKR RAFLKMCNSP EAFLSLRSHF VSSHALLCVS HWILGIGDRH
LSNFMINMET GGMIGIDFGH AFGSATQFLA VPELMPFRLT QQFVNLMQPL KESGLIQSIM
VHSLRAYRAA PDLLLNTMDV FVKEPSLDWK NFEVKQLKKG GTWRETVNTR EINWYPLQKV
NFAKRKLEGA NPAAITSEEL KLGFEKDAAF PGMKSVALGT EQHNIRAKLP AEGLSVEKQV
DCLLDQAMDP NVLGRVWVGW EPWI
//