ID   A0A3Q0SM91_AMPCI        Unreviewed;       329 AA.
AC   A0A3Q0SM91;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Ephrin-B2a {ECO:0000313|Ensembl:ENSACIP00000024027.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000024027.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000024027.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the ephrin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00884, ECO:0000256|RuleBase:RU004375}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00884}.
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DR   AlphaFoldDB; A0A3Q0SM91; -.
DR   STRING; 61819.ENSACIP00000024027; -.
DR   Ensembl; ENSACIT00000024663.1; ENSACIP00000024027.1; ENSACIG00000018664.1.
DR   GeneTree; ENSGT00940000155868; -.
DR   OMA; GSTRHND; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046875; F:ephrin receptor binding; IEA:InterPro.
DR   GO; GO:0035475; P:angioblast cell migration involved in selective angioblast sprouting; IEA:Ensembl.
DR   GO; GO:0007412; P:axon target recognition; IEA:Ensembl.
DR   GO; GO:0048013; P:ephrin receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0003404; P:optic vesicle morphogenesis; IEA:Ensembl.
DR   GO; GO:0021654; P:rhombomere boundary formation; IEA:Ensembl.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   GO; GO:0008039; P:synaptic target recognition; IEA:Ensembl.
DR   CDD; cd10426; Ephrin-B_Ectodomain; 1.
DR   Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR031328; Ephrin.
DR   InterPro; IPR034255; Ephrin-B_Ecto.
DR   InterPro; IPR019765; Ephrin_CS.
DR   InterPro; IPR001799; Ephrin_RBD.
DR   PANTHER; PTHR11304; EPHRIN; 1.
DR   PANTHER; PTHR11304:SF18; EPHRIN-B2; 1.
DR   Pfam; PF00812; Ephrin; 1.
DR   PRINTS; PR01347; EPHRIN.
DR   SUPFAM; SSF49503; Cupredoxins; 1.
DR   PROSITE; PS01299; EPHRIN_RBD_1; 1.
DR   PROSITE; PS51551; EPHRIN_RBD_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00884}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004375};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        218..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          35..171
FT                   /note="Ephrin RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51551"
FT   REGION          172..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..198
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        96..160
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00884"
SQ   SEQUENCE   329 AA;  36442 MW;  CF794AC3FB0A7866 CRC64;
     LAGLKARRLT MGDSMWRYYF GVLFIAFKVD LCRALILESI YWNTTNTKFV PGQGVVLYPQ
     IGDKLDIVCP RVDGGVGEGV EYYKVYMVPR EQLESCTITK ADTPLLNCVK PDQDVKFTLK
     FQEFSPNLWG LEFFRGKDYY IISTSNGTME GIDNQEGGVC KTKSMKIIMK VGQNPSDPVS
     PKDPTRVPHP PPHPFDKDPN NPNEVSDGKS SSVMGSEAAI FVAIASGSVI LIIIIVVLVL
     LLLKYRRRHR KHSPQHAATL SLSTLATPKR SGGGGNNNGS EPSDIIIPLR TADSVFCPHY
     EKVSGDYGHP VYIVQEMPPQ SPANIYYKV
//