ID   A0A3Q0SMU7_AMPCI        Unreviewed;       531 AA.
AC   A0A3Q0SMU7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=MACPF domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000024521.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000024521.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC       {ECO:0000256|ARBA:ARBA00009214}.
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DR   AlphaFoldDB; A0A3Q0SMU7; -.
DR   Ensembl; ENSACIT00000025166.1; ENSACIP00000024521.1; ENSACIG00000018253.1.
DR   GeneTree; ENSGT00530000063725; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR020863; MACPF_CS.
DR   PANTHER; PTHR46096; PERFORIN-1; 1.
DR   PANTHER; PTHR46096:SF1; ZGC:163021 PROTEIN; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF01823; MACPF; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00279; MACPF_1; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
PE   3: Inferred from homology;
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..531
FT                   /note="MACPF domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018789295"
FT   DOMAIN          31..341
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
FT   DOMAIN          344..469
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
SQ   SEQUENCE   531 AA;  60892 MW;  55AFDF15EDCA801B CRC64;
     MLSFTTPPPL YLSLLLFLLC NSPVLSCRTG NYIRCEAAPF VPGHNLIGEG FDVVTLHRKG
     AYMIDVMTYR KPDGTCTLCP NRHQGKMLQK LPASVVDWRA ISRCKVMKLI FCLLYQVGLS
     INKFVSASVG MGGTRSKVYN FATARTRQDR YSFSTHTVTC SHYRYRVSST PPLSSEFSRD
     VANLPTHYNS STRSQYDELI HTYGTHYIRQ VHLGGRMKRV TAIQTCLSTL NGLSSNEVHE
     EHLLTHIHQS AYLYFMFIKT SMQLIYIPVC NGWLGEFSLT HNNSLGFANW LNSLKDHPDV
     ASYFLRPMYQ LVPKGTKKAG MKAAIEQYLK DNSVSNYHSE RNCGWSTPNL AYNCCPQKAW
     RGELRVEIIR AWNLKGDHLG PTDSYAKMRF GSIFKQTPMI ESNNPRWNYI KSDFFNAIFL
     MKVDTHHNLH IEVWDEDLFY DDHLIACWTK VESGTRTYTC SHDGGDLQFK TILTCSPHLS
     GDQCHLNDFF FFIFKFVTLQ SIIMCFSKLS MAHRCLSYEI MQNVLLLAIK K
//