ID A0A3Q0SMU8_AMPCI Unreviewed; 569 AA.
AC A0A3Q0SMU8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=MACPF domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000024222.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000024222.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3Q0SMU8; -.
DR Ensembl; ENSACIT00000024862.1; ENSACIP00000024222.1; ENSACIG00000018253.1.
DR GeneTree; ENSGT00530000063725; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF1; ZGC:163021 PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..569
FT /note="MACPF domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018664854"
FT DOMAIN 31..339
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 342..460
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 569 AA; 65171 MW; 357C935E97856F9A CRC64;
MLSFTTPPPL YLSLLLFLLC NSPVLSCRTG NYIRCEAAPF VPGHNLIGEG FDVVTLHRKG
AYMIDVMTYR KPDGTCTLCP NRHQGKMLQK LPASVVDWRA ISRCKADIST STHISVGYSM
IYKDQTGPLL LQHTHCHLQP LSVSCEYHIY HKFRLTLDNL TLLICFFLPS YRVSSTPPLS
SEFSRDVANL PTHYNSSTRS QYDELIHTYG THYIRQVHLG GRMKRVTAIQ TCLSTLNGLS
SNEVHEEHLL THIHQSAYLY FMFIKTSMQL IYIPFSLTHN NSLGFANWLN SLKDHPDVAS
YFLRPMYQLV PKGTKKAGMK AAIEQYLKDN SVSNYHSERN CGWSTPNLAY NCCPQKAWRG
ELRVEIIRAW NLKGDHLGPT DSYAKMRFGS IFKQTPMIES NNPRWNAYYN LGTVDTHHNL
HIEVWDEDLF YDDHLIACWT KVESGTRTYT CSHDGGDLQF KTILTCSPHL SGDQNCSFCY
IHYWLHFSAH QVLLCAGFNM KSDCMEVYEK RILLFRFKCL NVASGLMLQI YFMFCKVWVS
PGQKCQDCGL CPVFFLLLPH FSAVSCHVS
//
