ID   A0A3Q0SP16_AMPCI        Unreviewed;       796 AA.
AC   A0A3Q0SP16;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Cadherin 6 {ECO:0000313|Ensembl:ENSACIP00000024986.1};
GN   Name=CDH6 {ECO:0000313|Ensembl:ENSACIP00000024986.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000024986.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000024986.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR   AlphaFoldDB; A0A3Q0SP16; -.
DR   STRING; 61819.ENSACIP00000024986; -.
DR   Ensembl; ENSACIT00000025637.1; ENSACIP00000024986.1; ENSACIG00000019351.1.
DR   GeneTree; ENSGT00940000154673; -.
DR   OMA; SYIMEVR; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 5.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027:SF428; CADHERIN 6; 1.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..796
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018673180"
FT   TRANSMEM        617..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          81..161
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          162..270
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          271..385
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          386..490
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          490..607
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   796 AA;  88591 MW;  D44611F0142AA94B CRC64;
     MDRRKVCIFM VLWAMAHLSS PGHGLRALRR TTGGRRGAGL TGQDANGVPL RRSKRGWMWN
     QFFLLEEYTG TDLQYVGKLH SDGDRGDGSV KYVLTGEGAG TLFKIDEKSG DIHATKRLDR
     EEKAYYILHA KAVNRFTNEA LEGESEFIIK IHDINDNEPR FTKDPYTARV PEMSDIGTSV
     IQVTATDADD ATYGNSAKVV YSILEGQPYF SVDPETGLIK TALPGMDREV KENYQVVIQA
     KDMAGQMGGL SGTTTVSITL SDVNDNPPRF TKTLYEFRVP ESIEVGSVVG VIRAMDADIG
     QNAEMDYRII GSDGPGMFEV TANRSTQDGV ILLRKPLDYE RKRQYSLRVQ VENVHINPRF
     YSKGPFRDEA TIKIVVDDVD EPPVFERASY VMEVKEDAPK NTAVGSVSAS DPDDKNSLVR
     YTIDRRTDMD RVFNIHAGNG SVFILRELDR EENAWHNISV IATEFTNPRQ ISRVPVYIRV
     LDVNDNAPTF ATNYETFVCE NAKANQVIQT VSAADPDAPL GGHRFFFNLA QEAAGKANFS
     VRDNKDNTAS ILTRRNSYSS LHKSIYHVPV VISDGEFPMQ SSTNTLTIRV CTCDREGNMK
     ACNAEALTAR AGLSTGALVA ILLCVIILLM IVVLFAALRR QRKKEPLIIS KEDVRDNVVS
     YNDEGGGEED TQAFDIGTLR NPEAIEESKQ RRDIVPEAFY PPIRRPVLPP TRDNNGDVRD
     FINQRLQDND SDPTAPPYDS LATYAYEGNG SVAESLSSLE SATTESDQDY NYLSEWGPRF
     KKLADLYGGD DSDRDS
//