ID A0A3Q0SP71_AMPCI Unreviewed; 1530 AA.
AC A0A3Q0SP71;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Adhesion G protein-coupled receptor B3 {ECO:0000313|Ensembl:ENSACIP00000026724.1};
GN Name=ADGRB3 {ECO:0000313|Ensembl:ENSACIP00000026724.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000026724.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000026724.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 61819.ENSACIP00000026724; -.
DR Ensembl; ENSACIT00000027421.1; ENSACIP00000026724.1; ENSACIG00000020657.1.
DR GeneTree; ENSGT00940000155081; -.
DR OMA; CESKNAF; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15989; 7tmB2_BAI3; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF40; ADHESION G PROTEIN-COUPLED RECEPTOR B3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1530
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018737679"
FT TRANSMEM 875..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 909..927
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 933..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..997
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1017..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1095..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1122..1146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 500..570
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 873..1147
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1530 AA; 171058 MW; 62B2B823AE3043C3 CRC64;
MKAVRNLLIY IFSTYLLVMF GLTGAQDYWC STLVKGVIYG SYSVTEMFPK NYTNCTWTLE
NPDPTKYSIY LKLYKRDLSC SEYSLLAYQF DHYSHEKINE LLKVNESIVY LCDSKNIYVF
LLYDKNFVQL RRVFPYDYNG LTPQKLDEEE KSIVEFLVLN KASPSQFGCQ VLCTWLENCL
KLEKGTVETC GIVYTKCTCP QHLGDGESES MLMLNNVVLP LNPQTEGCLS PQLQAGQICN
LTAEVKRPPK EEYGMIGEHT VKSQRPRSVH DTKALQEQAE SAKFMAQTGE SGAEEWSQWS
SCSVTCGQGS QVRTRTCVSP YGTHCSGPLR ESRVCNNTAP CPVHGVWEEW SPWSLCSFTC
GRGHRTRTRM CSPPQHGGRA CDGPETQTKL CNIALCPVDG QWQEWSSWSD CSVTCANGTQ
QRTRQCSAAA HGGSECRGHW AESRECHNPD CTANGQWNPW GPWSGCSKSC DGGWQRRARV
CQGAAVTGQQ CDGSGEEVRK CSDQRCPAPY EICPEDYAVS MVWRRTPSGE LAFNRCPPNA
TGTTSRRCSL DHRGMAFWEQ PSYARCITNE FRYLQQSVQG HLAKGQRMLA GDGMSQVTKT
LLDLTQRRNF YAGDLLSSVE ILRNVTETFK RASYEPSSDD VQNFFQIISN LLEEENKEKW
EDAQKIYPGA VELMQVIEEF IHIVGLGMKD FHNAYLMTGN LVASIQRLPA VSVMTDINFP
MKGRKGMVDW ARNSEDKVVI PKASFPPLDM EGSPVFILGT VLYKTLGLML PSPKNHTVVN
SKVIAVTVRP EPKATESHLE IELAHLANGT MNPYCALWDS TIMNDSWGAW STKGCKTVLT
DASHTKCLCE RVSTFAILAQ QPREITMEYS GVPSVTLIVG CGLSCLALIT LAVIYAVLWR
YIRSERSIIL LNFCLSIVCS NILILVGQTQ THNVGVCIMT TAFLHFFFLA SFCWVLTEAW
QSYMAVTGKV RTRLIRKRFL CLGWGLPALV VAVSMGFTKT KGYGTPLYCW LSLEGGLLYA
FVGPAAAVVL VNMVIGILVF NKLVSRDGIL DKKLKHRAGQ MSEPHTGLTL KCAKCGVVST
TALSATTASN AMASLWSSCV VLPLLALTWM SAVLAMTDKR SILFQILFAV FDSLQGFVIV
MVHCILRREV QDAFRCRLRN CQDPISGDAT GTFPNGHAQI MTDFEKDVDI ACRSALHKDM
GSCRAATITG TLSRISLNDE DDEKAPEGLN YSTLPGNIIS KVIIQQPSAL HMPLGVGELK
DPCMADSNAD MRRTVYLCTD DALRQSDQDM GGHDKDGHPV QSQMMETDYI VMPRASAVAV
SGSGNMPTLL KDDTKMNITM DTLPHERLMH YKMSPDFNIN PSGMDHMNVN LEQQYPSAPE
QMQNLPFEPR TAVKNFLAEM EESAGLSRSE TGSTISMSSL ERRKSRYSDL DFEKVMHTRK
RHMELFQELN QKFQTLDRFR DIPNMGSMDK AMPNKNPWES YNPACEYQNY ATMNVLESDT
KDSLEMTPAE WEKCVNLPLD VQEGDFQTEV
//
