ID   A0A3Q0SPN2_AMPCI        Unreviewed;       736 AA.
AC   A0A3Q0SPN2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Forkhead box protein P2 {ECO:0000256|ARBA:ARBA00040052};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000024792.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000024792.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   AlphaFoldDB; A0A3Q0SPN2; -.
DR   STRING; 61819.ENSACIP00000024792; -.
DR   Ensembl; ENSACIT00000025442.1; ENSACIP00000024792.1; ENSACIG00000019073.1.
DR   GeneTree; ENSGT00940000155480; -.
DR   OMA; XHLNNEH; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   CDD; cd20065; FH_FOXP2; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047412; FH_FOXP1_P2.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR032354; FOXP-CC.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR   PANTHER; PTHR45796:SF1; FORKHEAD BOX PROTEIN P2; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF16159; FOXP-CC; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          478..551
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        478..551
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          394..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          669..736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..297
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   736 AA;  79467 MW;  59088DE0AC65C05D CRC64;
     MMQESATETI SNSSMSQNGM STLSSSQLEA GSRDGRSSAG DTSSEVSTVE LLHLQQQQAL
     QAARQLLLQQ PGSGLKSPKS QDKQRPLQVP VSVAMMSPQV MTPQQMQQIL QQQVLSPQQL
     QALLQQQQAV MLQQVHQQQQ QQQLAAQQLV FQQQLLQMQQ LQQQQHLLNM QRQGLLTLPG
     PAPGQAALPG QTLPPQAGLS PAELQQLWKD VTGGGGHGME DNGIKHSGGG AGTGVGGGGL
     DLSTNNSSST TSSSNPAKAS PPISHHSIAN GQSPALNHRR ERERERERER ESSLHEESGG
     THPLYGHGVC KWPGCENICE DFGQFLKHLN SEHALDDRST AQCRVQMQVV QQLEIQLSKE
     RERLQAMMTH LHMRPSEPKS SPKPLNLVSS VTMSKNLPSA SPPNLPQTPT TPTAPITPMA
     AMPHVPSVLG GANVPSMGAM RRRHSDKYSM PLSSGGDTVF IFPEIAPNYE FYKNADVRPP
     FTYATLIRQA IMDSADMQLT LNEIYSWFTR TFAYFRRNAA TWKNAVRHNL SLHKCFVRVE
     NVKGAVWTVD EVEYQKRRSQ KITGSPSLVK NLPSSLGYGT ALNASLQAAL AETSLPLLGT
     PGLMGSGATG PMVGCHGLLG GDPSGLTAGS PPGQLGGSPP GLLGGSPPIT LSGSPPTLLQ
     SAHEELNGSV DHLDTNGHSS PRYSPPVHMP PIHIKEEPLN MDDDDCPMSL VTTANHSPEL
     EEDRELEEGN LSEDLE
//