ID   A0A3Q0SQP2_AMPCI        Unreviewed;       420 AA.
AC   A0A3Q0SQP2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Bone morphogenetic protein 5 {ECO:0000313|Ensembl:ENSACIP00000025646.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000025646.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000025646.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   AlphaFoldDB; A0A3Q0SQP2; -.
DR   Ensembl; ENSACIT00000026316.1; ENSACIP00000025646.1; ENSACIG00000019714.1.
DR   GeneTree; ENSGT00940000158644; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd19395; TGF_beta_BMP5; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   NCBIfam; NF033679; DNRLRE_dom; 1.
DR   PANTHER; PTHR11848:SF139; BONE MORPHOGENETIC PROTEIN 5; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          300..420
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          283..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   420 AA;  47537 MW;  33025FCDC65F3683 CRC64;
     VHIRLHVQAE VVYVALNLDF LLCVHCGLSD NHVHSSFIYR RLRNHERREI QREILSILGL
     PHRPRPFSPG KQASSAPLFM LDLYNAMAGV QQSPYRAAPL LGHSPALTTA HDTNFLNDAD
     MVMSFVNLVE KDKDFSHQRR HYKEFRFDLT QIPDGEAVTA AEFRIYKDRS HARYDNTTLK
     VSIYQVIKEY QNKDAETFLL DSKKVQASDG GWLVFDITAT SNHWVMNPQQ NLGLQLCVET
     VDGRSINIKS AGIIGRNGPQ SKQPFLVAFF KASGVLLRSV RAAGGKKKNH NRNKSNNQQQ
     SSKAPKTGDY NTSEQKQACK KHELYVSFRD LGWQDWIIAP EGYAAFYCDG ECSFPLNAHM
     NATNHAIVQT LVHLMFPDNV PKPCCAPTKL NAISVLYFDD SSNVILKKYR NMVVRSCGCH
//